Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE0TCN3)

DME Name	Ampc beta-lactamase (ampC)
Synonyms	Beta-lactamase ampC; Bacterial burkholderia beta-lactamase ampC; ampC; BCAS0156
Gene Name	ampC
UniProt ID	B4EPS2_BURCJ
INTEDE ID	DME1191
EC Number	EC: 3.5.2.6 Hydrolases Carbon-nitrogen hydrolase Cyclic amide hydrolase EC: 3.5.2.6
Lineage	Species: Burkholderia cenocepacia Kingdom: Bacteria Phylum: Proteobacteria Class: Betaproteobacteria Order: Burkholderiales Family: Burkholderiaceae Genus: Burkholderia Species: Burkholderia cenocepacia Subspecies: Burkholderia cenocepacia J2315
Tissue Distribution	Primarily distributed in human lung.
Sequence	MRFNATRFAATLLVAACATATAGRAAAVTQDDLRDTVTRQIAPLMKQYAIPGMAIGIVAD GKPYVFDYGVMSKQTGKPVTGDTLFEIGSVSKTLTATLASDAQEGGELSLADPAGKYLPE LQGKPFGVVTLLQLGTHTPGGTPLQVPDSIRDDAGLIRYLDAWRPAYAPGTHRKYSNVAI GMLGWLTAKAMHQDFATLMEQRLFPAIGMTHTYINVPAARMADYAQGYTKDGKPVRMTEG MLWQPAYGVRTTAADLLRFVQANMGMIHTAPRLQRAIERTHTGYFRAGPLTQDLIWEQYP YPVALPTLLAGNAPKMLFDAVPASAIQPPLAPNPATWINKTGSTGGFSTYVAFVPAKRIG IVMLANGNVPIEERVKAAYRILGSLGDAR
Function	This enzyme hydrolyzes beta-lactam.
KEGG Pathway	Two-component system (bcj02020 ) beta-Lactam resistance (bcj01501 )

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cefotaxime	DMEB837	Bacteremia	1A73	Approved	[1]
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References

1	Cell wall recycling-linked coregulation of AmpC and PenB beta-lactamases through ampD mutations in Burkholderia cenocepacia. Antimicrob Agents Chemother. 2015 Dec;59(12):7602-10.