Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE13AYF)

DME Name	Alpha-L-rhamnosidase (lrA)
Synonyms	Alpha-L-rhamnosidase T; Alpha-L-rhamnosidase N; Alpha-L-rhamnoside rhamnohydrolase; PY91_09320
Gene Name	lrA
UniProt ID	A0A179YH30_LACRH
INTEDE ID	DME1759
EC Number	EC: 3.2.1.40 Hydrolases Glycosylase O/S-glycosyl compound glycosidase EC: 3.2.1.40
Lineage	Species: Veillonella parvula Kingdom: Bacteria Phylum: Firmicutes Class: Negativicutes Order: Veillonellales Family: Veillonellaceae Genus: Veillonella Species: Veillonella parvula
Tissue Distribution	Primarily distributed in human gut.
Sequence	MPNITPSLLAPDHLRVNLQHFAYNIQAQPHFSWWNHSNRTGASQSAYQLTVFQRLQDRQN HNYLYDSGWVTSSNNTAVTAAKLSDQLVPGQLYYWQVRIKDNAGSISDFSQPAKLICADP SLPVKHGIWRQPQPKTAQELAHIGQVVFLRSPQLKINLSEVDTAVIVAVARGNEPVFAQS FDLYLNGHCLGVGSARQQEHDHGTEKTAIYYNVYEATDFLQDGANTVAALATASSDRQAF WCQLILYKHDGTKEVATTTDNTWRALDGSSAFGDYGVKIRTQYFGMVSENIDMRYYPQNW TDSAFDDHDWPLAWQNPYQLIADNEVLVPFRSENTERVEVHDRNKRVVTFSDQNYLLDLG KEIIGGLKVNLFSAFDQRVTVMMGEQLNDDGHVRHEMACGPDYIENWTLVKGQNQFTTLQ MKNFRYVELVGFEGDLPLDAINGWAMQQAFPDNESQFDSDSELLNREYELSKYTIKATNQ DVFVDSQARERRPYEGDLLVNANTSYSVSSNYSLARHSLDYLIDNPTWPEDYKLFAIEMA WLDYLYTGDDDLLQTRYTDLQYKLNRGKSAESFDGASQSFTGSLKNSQGVDNFDAAVGLV TNDGLVDWPISERDGFVEGTYNTPFNAIFHGAYATMAKIARVLHHPDDADRYQKRAEIIK TNLIDKLYDPQTGRFFDSLNADLSVNRHTSHHASAYALCYGVYTDQNMADRLSHFVANDG HFVGSIYFIYFMLKGLFEAGHAADAITLLTDPDNHKDHKSFAAILDSLKATIAPEAWSNA YKPNLTLSHPWGATPGLTIVQGVFGIVPLAPGFATFRVKVRPGNLKHLDLTTPSVKGLIT LHYRHEPTHQTLDVTVPMNTTAKVELPDDAQAIVVHDQYGKDWTASIEHDHDTLTIPMGR YQIQYQA
Function	This enzyme utilizes an inverting mechanism of hydrolysis, releasing beta-L-rhamnose. Substrates include naringin, rutin, quercitrin, hesperidin, dioscin, terpenyl glycosides and many other natural glycosides containing terminal alpha-L-rhamnose.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This DME

1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rutin	DMEHRAJ	Discovery agent	N.A.	Investigative	[1]
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References

1	Identification of rutin deglycosylated metabolites produced by human intestinal bacteria using UPLC-Q-TOF/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Jun 1;898:95-100.