Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE1DR6Y)

DME Name	S-adenosylhomocysteine nucleosidase (mtnN)
Synonyms	AdoHcy nucleosidase; DOA nucleosidase; MTA nucleosidase; MTA/SAH nucleosidase; MTAN; SAH nucleosidase; SRH nucleosidase; dAdo nucleosidase; 5'-deoxyadenosine nucleosidase; 5'-methylthioadenosine nucleosidase; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; mtnN
Gene Name	mtnN
UniProt ID	MTNN_KLEPN
INTEDE ID	DME1115
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
EC Number	EC: 3.2.2.9 Hydrolases Glycosylase N-Glycosyl compound glycosidase EC: 3.2.2.9
Lineage	Species: Klebsiella pneumoniae Kingdom: Bacteria Phylum: Proteobacteria Class: Gammaproteobacteria Order: Enterobacterales Family: Enterobacteriaceae Genus: Klebsiella Species: Klebsiella pneumoniae
Tissue Distribution	Primarily distributed in human gut.
Sequence	MKIGIIGAMEEEVTLLRDKIENRQTITIGGSEIYT
Function	This enzyme acts on S-methyl-5'-thioadenosine to give adenine and S-methyl-5-thioribose.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Discontinued Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylthioadenosine	DMC8J6F	Multiple sclerosis	8A40	Terminated	[1]
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References

1	Selective killing of Klebsiella pneumoniae by 5-trifluoromethylthioribose. Chemotherapeutic exploitation of the enzyme 5-methylthioribose kinase. J Biol Chem. 1990 Jan 15;265(2):831-7.