Details of Drug-Metabolizing Enzyme (DME)
General Information of Drug-Metabolizing Enzyme (DME) (ID: DE1QMDG)
| DME Name | Molybdopterin-dependent enzyme (molD) | ||||
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| Synonyms | Molybdopterin-dependent oxidoreductase; Oxidoreductase molD; molD | ||||
| Gene Name | molD | ||||
| UniProt ID | |||||
| INTEDE ID | |||||
| EC Number | EC: 1.1.1.40 | ||||
| Lineage | Species: Raoultella planticola | ||||
| Tissue Distribution | Primarily distributed in human gut. | ||||
| Sequence |
MTLARLALSGDLVRPSRLTVPDLLRWPQHRVAVSFECATSGTQHHRFTGPRLYDVLADAG
PGFDPVRRKDRLRFLIAVTGTDGHHALLSWAEIDPDFADAPVLLGVSIDDTPLDAAGPQL VLPQDRCGARHISQITAIRVDGSYRCAPVEVAAVP |
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| Function | This enzyme catalyzes the conversion of doxorubicin to 7-deoxydoxorubicinol and 7-deoxydoxorubicinolone via a reductive deglycosylation mechanism. | ||||
Molecular Interaction Atlas (MIA) of This DME
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1 Approved Drug(s) Metabolized by This DME
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