Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE21ZKX)

• DME Name: GH3 beta-glucosidase (BAD1610)
• Synonyms: Periplasmic beta-glucosidase GH3; Glucan endo-1 3-beta-D-glucosidase GH3; Beta-D-glucosidase GH3; Beta-D-glucoside glucohydrolase GH3; Beta-glucosidase GH3; GH3; BAD_1610
• Gene Name: BAD1610
• UniProt ID: A1A3V8_BIFAA
• INTEDE ID: DME1678
• EC Number:
  EC: 3.2.1.21
  Hydrolases
  Glycosylase
  O/S-glycosyl compound glycosidase
  EC: 3.2.1.21
• Lineage:
  Species: Bifidobacterium adolescentis
  Kingdom: Bacteria
  Phylum: Actinobacteria
  Class: Actinobacteria
  Order: Bifidobacteriales
  Family: Bifidobacteriaceae
  Genus: Bifidobacterium
  Species: Bifidobacterium adolescentis
• Tissue Distribution: Primarily distributed in human gut.
• Sequence:
  MTMPRSMYNHADKQEDKEKSYIELDSTETEIIKYLNDNYKDVILLVKSSAAMELDWLKQY
  PNIKAVVYSQNVTNALAKVFSGEVNPSGRTVDTFAADALASPAAQNFGSYQYYDENGKAT
  KYNYVDYAEGIYVGYKYYETRYEDKVLGQGNAGDYDYAKEVVYPFGYGLSYTDFKWSDFS
  VARHGNDFVATVTVTNTGDTAGKDVVELYAQSPYTDYDKRNAVEKASVNLVGYGKTSELK
  PGTSETVRITFGKDQLKAYDYKGAKTYILDAGQYRFTAATDANQAVNNILADKGKTVADG
  MTSEGDKTMVASWTPENTDADTTTFASDSTTGKAISNLFDAASDPEVAYLSRSDWTGTFP
  KHYGESSGEINTWGNEINCKDSDGNNASCTWKKTASTKLIKHLEGNDSGTTVDKDSIMDT
  PTFGKKNGLKVSDMRGLAYDDAQWDKILDELTEDDYNQLIYFSGYGVDYIKSVDKPFQTD
  ADSATGWMYGGTGKTFPSIMMLTQTWNAQLAEDLGEMMGNEALLGGANGWYAPAMNIHRT
  PFSGRNGEYYSEDGYMSGSMASLEVKGAATKGVYSYIKHFALNDQENHRGDRPGNFSVAT
  WSNEQAIREIYLKPFDMCMHLGDMDMKTVVKKSDGTYENKVVKTPIAKGVMTSFNRIGAT
  WTGGSHALIQQLLRDEWGFNGLIITDNANTGKFMSPYQMLEAGADIKLLNVSDDPTGEKL
  DFNDAATYHYARQAMHHLLYTVANTNCMNGALPGAGFKFSNGMKTIQIVFNTVCSVILAM
  LAFFSVWRWMPGTIKRVAARKEARVARKAARKAAKG
• Function: This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosides.
• KEGG Pathway:
  Biosynthesis of secondary metabolites (bad01110)
  Cyanoamino acid metabolism (bad00460)
  Metabolic pathways (bad01100)
  Starch and sucrose metabolism (bad00500)

Molecular Interaction Atlas (MIA) of This DME

2 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PNB-D-glucoside	DMBK8QI	N. A.	N. A.	Investigative	[1]
PNB-D-xyloside	DMWPECH	N. A.	N. A.	Investigative	[1]

References

• [1] Structural and biochemical characterization of a GH3 beta-glucosidase from the probiotic bacteria Bifidobacterium adolescentis. Biochimie. 2018 May;148:107-115.