Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE26IS8)

• DME Name: Beta-galactosidase (bgaB)
• Synonyms: Beta-galactosidase/glucuronidase; Beta-galactosidase BgaBeta; Beta-Gal II; Beta-gal; JCM16774_1906; Lactase
• Gene Name: bgaB
• UniProt ID: A0A510JCD5_9FUSO
• INTEDE ID: DME1155
• EC Number:
  EC: 3.2.1.23
  Hydrolases
  Glycosylase
  O/S-glycosyl compound glycosidase
  EC: 3.2.1.23
• Lineage:
  Species: Leptotrichia goodfellowii
  Kingdom: Bacteria
  Phylum: Fusobacteria
  Class: Fusobacteriia
  Order: Fusobacteriales
  Family: Leptotrichiaceae
  Genus: Leptotrichia
  Species: Leptotrichia goodfellowii
  Subspecies: Leptotrichia goodfellowii CCUG 32286
• Tissue Distribution: Primarily distributed in human gut.
• Sequence:
  MNKWEDFNILSENTMEPRNHFFRYENLEKAKTFNRYYSENFLLLNGIWKFKYFKNPHEVL
  EEYHSQITADREIQVPNMWQFEGYGQPHYTDEGFPFPIDFPYVSTDNPTGLYQRYFYLSK
  EFKNKDIILKAEGIESYYELYINGHYVGLNKGSRLITEFDITDFVNISKENLISIKVLQW
  SDSTYLEDQDMWWISGIFRDIYIYSKNRFCIEKYVVKTEMKNDYKDSDLIIDLELNTEKF
  LGKNLEIEFTLYNEKEKIFSEKIVPKKKNIKLKKSIKKIIEWNPENPYLYDLFIILRKDK
  KIIEVIPQKVGFRYIEVKKGLMYLNGKYFMMHGVNRHDNDHISGRTVGFERMEKDIILMK
  QNNINSVRTAHYPNSPRFYELCDKYGLMVLSEMDIETHGFVNTDDFNMLINNEKYKKMFV
  SRVVRQVISQINHPSIIIWSLGNESGYGVNVTHMTNEIKKVDTTRLIHYEEDRYAEDVDI
  ISTMYSRVQMMDNFGRFPSDKPRIICEYAHAMGNGPGGLKEYQEVFYKYPSIQGHFVWEW
  CDHGIYDKERDIYKYGGDYEDYPNNLNFCMDGLIFSNQKEGPGLKEYKQVISPVLIKKIS
  DIEYKVINRYWFSNLKDIKIYYEIFNGKKLTECNELENIENGSIIKFPRKIVNASIINFK
  VYKKNKTDYSAENHLLSVYQFQLEEKKQTYEKDNKIPEFHKITENNNEIVITGKNFSIKF
  SKLNGKLISYNYSGLELIKKPGSINLYKPVIDNHKKENLKWWLPFYFSVIQEHFRKMKIV
  KEKNKVKISVNSILAPPVYDFGLNCEYEYEIYGNGQINIKLKGKKYGKFLGIIPKIGFEI
  GLNKDLQNVKYYGRGENENYTDSKEASIIGFYKTTVDNMFINYPYPQDNGNHQDTKELYL
  TNHFGQGMSVKSENGLNFSAWNYTKENIDKAKHPDELIKSDFITLNLDYKILGLGSNSWG
  SEVLETYRVYLEDFEYGFSINTYND
• Function: This enzyme hydrolyzes alpha-L-arabinoside and beta-D-fucosides and beta-D-glucosides.

Molecular Interaction Atlas (MIA) of This DME

1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
D-mannose	DMT6X03	Discovery agent	N.A.	Investigative	[1], [2]

References

• [1] Genetic diversity of Leptotrichia and description of Leptotrichia goodfellowii sp. nov., Leptotrichia hofstadii sp. nov., Leptotrichia shahii sp. nov. and Leptotrichia wadei sp. nov. Int J Syst Evol Microbiol. 2004 Mar;54(Pt 2):583-592.
• [2] Leptotrichia species in human infections II. J Oral Microbiol. 2017 Sep 15;9(1):1368848.