| DME Name |
VanB ligase (vanB)
|
| Synonyms |
Vancomycin B-type resistance protein VanB; D-alanylalanine synthetase VanB; D-alanine--D-alanine ligase VanB; D-Ala-D-Ala ligase VanB; vanB |
| Gene Name |
vanB
|
| UniProt ID |
|
| INTEDE ID |
|
| EC Number |
EC: 6.3.2.4
- Ligase
- Carbon-nitrogen ligase
- Peptide synthase
- EC: 6.3.2.4
|
| Lineage |
Species: Desulfitobacterium hafniense
- Kingdom: Bacteria
- Phylum: Firmicutes
- Class: Clostridia
- Order: Clostridiales
- Family: Peptococcaceae
- Genus: Desulfitobacterium
- Species: Desulfitobacterium hafniense
- Subspecies: Desulfitobacterium hafniense DCB-2
- Subspecies: Desulfitobacterium hafniense DP7
- Subspecies: Desulfitobacterium hafniense G2
- Subspecies: Desulfitobacterium hafniense PCE-S
- Subspecies: Desulfitobacterium hafniense PCP-1
- Subspecies: Desulfitobacterium hafniense TCP-A
- Subspecies: Desulfitobacterium hafniense TCE1
- Subspecies: Desulfitobacterium hafniense Y51
|
| Tissue Distribution |
Primarily distributed in human gut.
|
| Sequence |
MNRIKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVWKLCKKPCTEWE
ADSLPAILSPDRKTHGLLVMKESEYETRRIDVAFPVLHGKCGEDGAIQGLFVLSGIPYVG
CDIQSSAACMDKSLAYILTKNAGIAVPEFQMIDKGDKPEAGALTYPVFVKPARSGSSFGV
TKVNGTEELNAAIEAAGQYDGKILIEQAISGCEVGCAVMGNEDDLIVGEVDQIRLSHGIF
RIHQENEPEKGSENAMITVPADIPVEERNRVQETAKKVYRVLGCRGLARVDLFLQEDGGI
VLNEVNTLPGFTSYSRYPRMMAAAGITLPALIDSLITLALKR
|
| Function |
This enzyme produces the depsipeptide D-alanyl-(R)-lactate, which can be incorporated into the peptidoglycan pentapeptide instead of the usual D-alanyl-D-alanine dipeptide. The resulting peptidoglycan does not bind the glycopeptide antibiotics vancomycin and teicoplanin, conferring resistance on the bacteria.
|
|
|
|
|
|
|
