Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE3HL9N)

• DME Name: Tyrosine decarboxylase (tdc)
• Synonyms: Levodopa decarboxylase; L-dopa decarboxylase; L-tyrosine decarboxylase; TDC; tdc; tdcA; EF_0634
• Gene Name: tdc
• UniProt ID: TYRDC_ENTFA
• INTEDE ID: DME1061
• Gene ID: 1199535
• EC Number:
  EC: 4.1.1.25
  Lyases
  Carbon-carbon lyase
  Carboxy-lyase
  EC: 4.1.1.25
• Lineage:
  Species: Enterococcus faecalis
  Kingdom: Bacteria
  Phylum: Firmicutes
  Class: Bacilli
  Order: Lactobacillales
  Family: Enterococcaceae
  Genus: Enterococcus
  Species: Enterococcus faecalis
• Tissue Distribution: Primarily distributed in human gut.
• Sequence:
  MKNEKLAKGEMNLNALFIGDKAENGQLYKDLLIDLVDEHLGWRQNYMPQDMPVISSQERT
  SESYEKTVNHMKDVLNEISSRMRTHSVPWHTAGRYWGHMNSETLMPSLLAYNFAMLWNGN
  NVAYESSPATSQMEEEVGHEFAHLMSYKNGWGHIVADGSLANLEGLWYARNIKSLPFAMK
  EVKPELVAGKSDWELLNMPTKEIMDLLESAEDEIDEIKAHSARSGKHLQAIGKWLVPQTK
  HYSWLKAADIIGIGLDQVIPVPVDHNYRMDINELEKIVRGLAEEQIPVLGVVGVVGSTEE
  GAVDSIDKIIALRDELMKDGIYYYVHVDAAYGGYGRAIFLDEDNNFIPYEDLQDVHEEYG
  VFKEKKEHISREVYDAYKAIELAESVTIDPHKMGYIPYSAGGIVIQDIRMRDVISYFATY
  VFEKGADIPALLGAYILEGSKAGATAASVWAAHHVLPLNVAGYGKLIGASIEGSHHFYNF
  LNDLTFKVGDKEIEVHTLTHPDFNMVDYVFKEKGNDDLVAMNKLNHDVYDYASYVKGNIY
  NNEFITSHTDFAIPDYGNSPLKFVNSLGFSDEEWNRAGKVTVLRAAVMTPYMNDKEEFDV
  YAPKIQAALQEKLEQIYDVK
• Function: This enzyme catalyzes the decarboxylation of L-tyrosine to produce tyramine.
• KEGG Pathway:
  Metabolic pathways (efa01100)
  Tyrosine metabolism (efa00350)

Molecular Interaction Atlas (MIA) of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[1], [2]

References

• [1] Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism. Science. 2019 Jun 14;364(6445). pii: eaau6323.
• [2] Gut bacterial tyrosine decarboxylases restrict levels of levodopa in the treatment of Parkinson's disease. Nat Commun. 2019 Jan 18;10(1):310.