Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE473X0)

• DME Name: Beta-glucuronidase (uidA)
• Synonyms: Beta-galactosidase/beta-glucuronidase; Beta-galactosidase BgaB; ERS852572_00863; uidA
• Gene Name: uidA
• UniProt ID: A0A173S9G2_9FIRM
• INTEDE ID: DME1937
• EC Number:
  EC: 3.2.1.31
  Hydrolases
  Glycosylase
  O/S-glycosyl compound glycosidase
  EC: 3.2.1.31
• Lineage:
  Species: Roseburia intestinalis
  Kingdom: Bacteria
  Phylum: Firmicutes
  Class: Clostridia
  Order: Clostridiales
  Family: Lachnospiraceae
  Genus: Roseburia
  Species: Roseburia intestinalis
• Tissue Distribution: Primarily distributed in human gut.
• Sequence:
  MLYPQENKIRGIIDLNGVWDFALGTTEEPGDAVTLPEQMEPIAVPASYNDQKDDIAYRNH
  YGYAYYRRNITVPSYYKGQRLVLRFDAVTHFAKIYLNGVLLTQHKGGFLPFEVDITDKLC
  AGESAELVVAVDNRINHSTLPVGNEEGTSFMGADNVGVPGVEAAKRWRKPQNLPNFDFFN
  YAGINRPVRIYTTPKAYIKDVTLVTDIRGTDGIVNYQVKTSDTDGQEVVLQILDANGNEV
  AQAKGTSGEIVIPDAKLWEPYPGTPYLYTAAVTFGDDYYEEPFGVRTVRVEGTSFLINGK
  PFYFKGFGKHEDSAFHGRGMDVCLDVKDVNLIHWLHANSFRTSHYPYAEEMYRLCDREGI
  VIIDEVPAVGIGAGAGINPYETFPIREHHEQVIKDMIARDKNHPCVVMWSLGNEPDTENF
  PESAYKYWHSLYELAHETDPSNRPVTLVCCQNNYEKDMVTRSMDVVCINRYYGWYNLSGD
  LDAACYGLNLELDFWEKQNKPVMITEYGADAVAGIHECVPEMFSEEFQVEFYKRQNAQFD
  KRKFFIGEHVWNFADFATVQGCMRVDGNKKGLFTRERRPKMAAHYFRERWGEVPDFGYKR
• Function: This enzyme takes part in glucuronoside catabolic process. It catalyzes the hydrolysis of beta-glucuronide containing substrates.

Molecular Interaction Atlas (MIA) of This DME

1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin glucuronide	DMSBENK	N. A.	N. A.	Investigative	[1]

References

• [1] Developing a metagenomic view of xenobiotic metabolism. Pharmacol Res. 2013 Mar;69(1):21-31.