General Information of Drug-Metabolizing Enzyme (DME) (ID: DE49HWX)

DME Name CDP-alcohol phosphatidyltransferase (pgsA)
Synonyms CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; pgsA; AXK38_10040; CYK18_09100; D8842_08295; FBF73_01305; SK1126_1848; SK642_1900
Gene Name pgsA
UniProt ID
A0A081Q830_STRMT
INTEDE ID
DME1149
EC Number EC: 2.7.8.5
Transferase
Kinase
Phosphotransferase
EC: 2.7.8.5
Lineage Species: Streptococcus mitis
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Streptococcaceae
Genus: Streptococcus
Species: Streptococcus mitis
Tissue Distribution Primarily distributed in human oral cavity.
Sequence
MKKEQIPNLLTIGRILFIPIFIFILTVGNSIESHIVAAIIFAIASITDYLDGYLARKWNV
VSNFGKFADPMADKLLVMSAFIMLIELGMAPAWIVAVIICRELAVTGLRLLLVETGGTVL
AAAMPGKIKTFSQMFAIIFLLLHWTLIGQVLLYVALFFTIYSGYDYFKGSAYVFKGTFGS
K
Function This enzyme catalyzes the committed step in the biosynthesis of acidic phospholipids known by the common names phophatidylglycerols and cardiolipins.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DME
1 Approved Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
Daptomycin DMFDQ3I Bacterial infection 1A00-1C4Z Approved [1]

References

1 Mutations in cdsA and pgsA correlate with daptomycin resistance in Streptococcus mitis and S. oralis. Antimicrob Agents Chemother. 2019 Jan 29;63(2). pii: e01531-18.