Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE49HWX)

DME Name	CDP-alcohol phosphatidyltransferase (pgsA)
Synonyms	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; pgsA; AXK38_10040; CYK18_09100; D8842_08295; FBF73_01305; SK1126_1848; SK642_1900
Gene Name	pgsA
UniProt ID	A0A081Q830_STRMT
INTEDE ID	DME1149
EC Number	EC: 2.7.8.5 Transferase Kinase Phosphotransferase EC: 2.7.8.5
Lineage	Species: Streptococcus mitis Kingdom: Bacteria Phylum: Firmicutes Class: Bacilli Order: Lactobacillales Family: Streptococcaceae Genus: Streptococcus Species: Streptococcus mitis
Tissue Distribution	Primarily distributed in human oral cavity.
Sequence	MKKEQIPNLLTIGRILFIPIFIFILTVGNSIESHIVAAIIFAIASITDYLDGYLARKWNV VSNFGKFADPMADKLLVMSAFIMLIELGMAPAWIVAVIICRELAVTGLRLLLVETGGTVL AAAMPGKIKTFSQMFAIIFLLLHWTLIGQVLLYVALFFTIYSGYDYFKGSAYVFKGTFGS K
Function	This enzyme catalyzes the committed step in the biosynthesis of acidic phospholipids known by the common names phophatidylglycerols and cardiolipins.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Daptomycin	DMFDQ3I	Bacterial infection	1A00-1C4Z	Approved	[1]
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References

1	Mutations in cdsA and pgsA correlate with daptomycin resistance in Streptococcus mitis and S. oralis. Antimicrob Agents Chemother. 2019 Jan 29;63(2). pii: e01531-18.