Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE4IPGZ)

DME Name	Sucrose phosphorylase (Spase)
Synonyms	Sucrose glucosyltransferase; Glucosyltransferase-A; SPase; GTF-A; SP; treY; D7H66_05705; gtfA
Gene Name	gtfA
UniProt ID	Q7WWQ5_LACAI
INTEDE ID	DME1718
EC Number	EC: 2.4.1.7 Transferase Glycosyltransferases Hexosyltransferase EC: 2.4.1.7
Lineage	Species: Lactobacillus acidophilus Kingdom: Bacteria Phylum: Firmicutes Class: Bacilli Order: Lactobacillales Family: Lactobacillaceae Genus: Lactobacillus Species: Lactobacillus acidophilus
Tissue Distribution	Primarily distributed in human gut.
Sequence	MKLQNKAILITYPDSLGHNLKDLDHVMDRYFNKTIGGIHLLPFFPSNGDRGFSPTRYDVV EPKFGSWEDVEKLSQKYYLMFDFMINHLSKKSSYFEDFEAKHDKSKYSDLFLSWDKFWPK GRPTKEDIDLIYKRKDKAPYQNIKFEDGTHEKMWNTFGPDQMDLDVRTKTTQDFIKHNLQ NLSKHGASLIRLDAFAYAIKKLDTNDFFVEPEIWNLLEKVNDYLKDTPTTILPEIHEHYT MPFKVAEHGYFIYDFALPMVLLYSLYSGNSTQLAAWLKKCPMKQFTTLDTHDGLGVVDAK DILTDDQISYTTNELYKIGANVKKKYSSAEYHNLDIYQINTTYYSALGNDDKKYFIARLL QIFAPGIPQIYYVGLLAGENDIQLLEKTKEGRDINRHYYDLDEIAEQVQRPVVKSLIKLL EFRNSVPAFDLEGSIKVETPSEHEIIVTRSNKAGTEVASTYVDFKNLDYQVKYNDQVFNF
Function	This enzyme catalyzes the conversion of sucrose to D-fructose and alpha-D-glucose-1-phosphate.
KEGG Pathway	Metabolic pathways (laf01100 ) Starch and sucrose metabolism (laf00500 )

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Raffinose	DMVHDOS	N. A.	N. A.	Investigative	[1]
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References

1	Differential proteome and cellular adhesion analyses of the probiotic bacterium Lactobacillus acidophilus NCFM grown on raffinose - an emerging prebiotic. Proteomics. 2016 May;16(9):1361-75.