Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE4WCJL)

DME Name	Beta-glucosidase (bglA)
Synonyms	Periplasmic beta-glucosidase; Glucan endo-1 3-beta-D-glucosidase; Beta-D-glucosidase; BN702_00404
Gene Name	bglA
UniProt ID	R5RU84_9BACE
INTEDE ID	DME1479
EC Number	EC: 3.2.1.21 Hydrolases Glycosylase O/S-glycosyl compound glycosidase EC: 3.2.1.21
Lineage	Species: Veillonella parvula Kingdom: Bacteria Phylum: Firmicutes Class: Negativicutes Order: Veillonellales Family: Veillonellaceae Genus: Veillonella Species: Veillonella parvula
Tissue Distribution	Primarily distributed in human gut.
Sequence	MHSKQKGTFPTTPRILAAFLMAFFLMVSCGCSTKIGQPVLPDSEGNGSETETPDDNKPDE NKPGENEQTPDSEGYVLMWSDEFDSNSLDTGKWRIEVNGNGGGNAELQYYDESGISLGKD SEYGNSALKITAKREQRNGKAFVSGRLNTSGHFQFCYGKVEGRIRLPRTANGLWPAFWLL GADFQTNSWPRCGEIDIMEMGNAEGIKKGTQDRFFNGACHWGYYKGSAYPNYAHSTTNSY SIQDGNYHTYTLIWTPQSVKMYLDRDLHPNASPYYEMDIVNKDDDWGVGYYFHHNFFIIL NLAVGGYFTGILQPEGITALPNNGDSATMFVDWVRVYQKKQ
Function	This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosides.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Clinical Trial Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CONTIGOSIDE B	DMX9V8K	Thrombosis	DB61-GB90	Phase 2/3	[1]
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References

1	Identification of rutin deglycosylated metabolites produced by human intestinal bacteria using UPLC-Q-TOF/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Jun 1;898:95-100.