Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE4ZRTV)

DME Name	Glycerol/diol dehydratase (dhaB)
Synonyms	Glycerol dehydratase; Propanediol dehydratase pduC; A4U99_10800; ERS852504_00022; dhaB; pduC
Gene Name	dhaB
UniProt ID	A0A174IA87_FLAPL
INTEDE ID	DME1869
Gene ID	33071355
EC Number	EC: 4.2.1.30 Lyases Carbon-oxygen lyase Hydro-lyase EC: 4.2.1.30
Lineage	Species: Flavonifractor plautii Kingdom: Bacteria Phylum: Firmicutes Class: Clostridia Order: Clostridiales Family: Ruminococcaceae Genus: Flavonifractor Species: Flavonifractor plautii
Tissue Distribution	Primarily distributed in human gut.
Sequence	MKSKRFEVLAARPVNQDGYVQEWPEVGLIAMNSPFDPKPSIKIENGVITEMDGKCRADFD MLDTFIADHAIRLGNAEKAMAMDSLEIARKIVDINVSREEILDITLSLTPAKLTEVVGKL NIVEIMMGMTKMRARMMPANQCHVTNVRDNPVQIAADAAEAGVRGFAEMETTVAVARYAP FNAMALFVGAQVGRPGVMTQCALEEATELQLGMRGFTTYAETISVYGTEPVFMDGDDTPY SKAFLASCYASRGLKMRFTSGTGSEVQMGYAEGKSMLYLEARCLAVTKGAGVQGTQNGSV SCIGVPAGVPGGIRAVAAENLIAMLLDLESTTSNDQTFTHSDLRRVARTVPQLFSGTDYI CSGYSATPNYDNMFAGSNWDAEDYDDWTIIQRDMKIDGGLQPVREEDVLKARNKAARALQ GMFRELGLPEITDAEVEAATYANGSNDMPERNVNEDLKAIEDMMARKVTGVDFVKALDRA GFPDVAHNIYNMLRQKVAGDYLHTASIFDEQFHVLSAVNVPNEYHGPMTGYQISEERWNQ LKNIPNAIRPEDI
Function	This enzyme has two forms. One form requires a cobamide coenzyme, while the other is a glycyl radical enzyme.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE	DMNQL17	Discovery agent	N.A.	Investigative	[1]
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References

1	Gut microbial beta-glucuronidase and glycerol/diol dehydratase activity contribute to dietary heterocyclic amine biotransformation. BMC Microbiol. 2019 May 16;19(1):99.