Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE5ME8A)

DME Name	Metallothionein-1A (MT1A)
Synonyms	Metallothionein-IA; MT-1A; MT-IA; MT1A; MT1S; OMIM: 156350; GeneCards: MT1A
Gene Name	MT1A
UniProt ID	MT1A_HUMAN
INTEDE ID	DME0094
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Gene ID	4489
EC Number	EC: 1.8.5.1 Oxidoreductase Sulfur donor oxidoreductase Quinone acceptor oxidoreductase EC: 1.8.5.1
Lineage	Species: Homo sapiens Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens
Sequence	MDPNCSCATGGSCTCTGSCKCKECKCTSCKKSCCSCCPMSCAKCAQGCICKGASEKCSCC A
Function	This enzyme acts as anti-oxidants, protect against hydroxyl free radicals, are important in homeostatic control of metal in the cell, and play a role in detoxification of heavy metals.
KEGG Pathway	Mineral absorption (hsa04978 )
Reactome Pathway	Metallothioneins bind metals (R-HSA-5661231 )

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

3 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carboplatin	DMG281S	Adenocarcinoma	2D40	Approved	[1]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[2]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[1]
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References

1	PharmGKB: A worldwide resource for pharmacogenomic information. Wiley Interdiscip Rev Syst Biol Med. 2018 Jul;10(4):e1417. (ID: PA150642262)
2	Role of metallothionein in cisplatin sensitivity of germ-cell tumours. Int J Cancer. 2000 Mar 15;85(6):777-81.