Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE5Q9XD)

DME Name	Alpha-hydroxysteroid dehydrogenase (12AH)
Synonyms	Hydroxysteroid dehydrogenase alpha; 12-alpha-HSD; 12-alpha-hydroxysteroid dehydrogenase; 12AH; HSD12A
Gene Name	12AH
UniProt ID	12AH_CLOS4
INTEDE ID	DME1752
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
EC Number	EC: 1.1.1.176 Oxidoreductase CH-OH donor oxidoreductase NAD/NADP oxidoreductase EC: 1.1.1.176
Lineage	Species: Clostridium leptum Kingdom: Bacteria Phylum: Firmicutes Class: Clostridia Order: Clostridiales Family: Ruminococcaceae Genus: Clostridium Species: Clostridium leptum
Tissue Distribution	Primarily distributed in human gut.
Sequence	MIFDGKVAIITGGGKAKSIGYGIAVAYAK
Function	This enzyme catalyzes the oxidation of the 12alpha-hydroxy group of bile acids, both in their free and conjugated form. Abd it also acts on bile alcohols.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Oxolithocholic acid	DMRKA08	N. A.	N. A.	Investigative	[1]
------------------------------------------------------------------------------------

References

1	Metabolism of oxo-bile acids and characterization of recombinant 12alpha-hydroxysteroid dehydrogenases from bile acid 7alpha-dehydroxylating human gut bacteria. Appl Environ Microbiol. 2018 May 1;84(10). pii: e00235-18.