Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE5Z9QK)

• DME Name: Beta-glucuronidase (uidA)
• Synonyms: Beta-galactosidase/beta-glucuronidase; Beta-galactosidase BgaB; ERS852462_01204; ERS852510_02901; uidA_1; uidA_2
• Gene Name: uidA_1
• UniProt ID: A0A174H0E7_BACUN
• INTEDE ID: DME1193
• EC Number:
  EC: 3.2.1.31
  Hydrolases
  Glycosylase
  O/S-glycosyl compound glycosidase
  EC: 3.2.1.31
• Lineage:
  Species: Bacteroides uniformis
  Kingdom: Bacteria
  Phylum: Bacteroidetes
  Class: Bacteroidia
  Order: Bacteroidales
  Family: Bacteroidaceae
  Genus: Bacteroides
  Species: Bacteroides uniformis
  Subspecies: Bacteroides uniformis str. 3978 T3 i
• Tissue Distribution: Primarily distributed in human gut.
• Sequence:
  MITCLLAVSVLGGKSQAQDLLSNVYGRDYQLLNGKWGAIVDLYDQGERMQVYKNRKPQDN
  KQFYEYSFDGGLVLNVPADFNSQMPELKFYEGTVWYGRSFDTPKTDGKRLFLYFGAVSYR
  SKIYLNGEKIASHEGGFTPFQVEITDKVKQKDNFLVVKVNNTRTTDAIPAMSFDWWNYGG
  ITRDVMLVSVPQSYIKDHFIQLDKVQSNLIRAKVTLSEAKPGINVQVAIPELGIRQNMTT
  DANGIAQATIKTKKLQRWSPDAPKLYDVTITSESDRLNEQIGFRNLYVKGEDIYLNDQPI
  FLRSISFHEEIPQRRGRAFSEADATMLLSEAKELGANMIRLAHYPQNEYTVRLAERMGFL
  LWEEIPIWQGIDFKNTATREKAGRMIKEMVMRDKNRCSVAFWGIANETATSAPRNEFLKH
  MKQCCLDIDSTRLITAAFDLVRFNRESRDFEMNDSIINILDMVAINKYMGWYHDWPLAPD
  QAVWNVAPGKPLFISEFGGEALYGKHGDAEVKSSWSEDYQAQLYKDNLEMFKHIPNLRGT
  SPWILLDFRSPFRFHPHQGGEWNRKGLVSDQGQRKKAWYIMRDYYNQKKTEQ
• Function: This enzyme takes part in glucuronoside catabolic process. It catalyzes the hydrolysis of beta-glucuronide containing substrates.

Molecular Interaction Atlas (MIA) of This DME

2 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MUG trihydrate	DM16F75	N. A.	N. A.	Investigative	[1]
SN-38G	DM2UVNB	N. A.	N. A.	Investigative	[1]

References

• [1] Three structurally and functionally distinct beta-glucuronidases from the human gut microbe Bacteroides uniformis. J Biol Chem. 2018 Nov 30;293(48):18559-18573.