Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE65RJO)

DME Name	Beta-glucuronidase (uidA)
Synonyms	Beta-galactosidase/beta-glucuronidase; Beta-galactosidase BgaB; DW705_07115
Gene Name	uidA
UniProt ID	A0A3R6CAL9_9BACT
INTEDE ID	DME1910
EC Number	EC: 3.2.1.31 Hydrolases Glycosylase O/S-glycosyl compound glycosidase EC: 3.2.1.31
Lineage	Species: Parabacteroides merdae Kingdom: Bacteria Phylum: Bacteroidetes Class: Bacteroidia Order: Bacteroidales Family: Tannerellaceae Genus: Parabacteroides Species: Parabacteroides merdae
Tissue Distribution	Primarily distributed in human gut.
Sequence	MKRISIAFLSLFLCVASVWSMPRPEYPRPQFERAGWVNLNGEWTCSFDFGGSGMEREFYK SKGFDKKITVPFCPESKLSGIGYMDFINHFWYQRPITIPQEWNGKNILLNFGAVYYKSEV YIDGVLANRHFGGTSSFAVDITSLVKPGQTHSLVVYVESDVRGAKQAAGKQNLQYASYGC NYTRTTGIWQTVWMEAVHPEGLQSVQLLTDIDQQQLVVRPRFYKEAGGKLQVTLKDNGKV VASRTVSASSLSSVVLPVKKMKTWSPESPFLYDLEYKVLDKNGNIIDEVNGYAGMRKVHI EGNKIYLNNKPYYQRLVLDQGFYPDGIWTAPSDEALKRDIELSMEAGFNGARLHQKVFEE RFYYWADKMGYLTWGEASSWGMDCNDTETARNFITEWSEIVQRDRNHPSLLIWTPTNEEF WPDRVQYPRLMHDLYNLTKMIDPTRPFHGASGGTHIATDIWTVHNYEQDPAKLKEKLYNG GKLMEAPKWEIHLMPMNIGYNGLKYTDQYAFPEYKKDMPYLVDEFGGIKWNPSQQMESAQ NTSWGYGEPPRSLEEFYARLEGQVDAVLSLSNDIWGYCYTQLTDVEQEQNGIYYYDRTPK FDMKRIHAIFSKTPESK
Function	This enzyme takes part in glucuronoside catabolic process. It catalyzes the hydrolysis of beta-glucuronide containing substrates.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

2 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Kaltostat	DMFR79L	N. A.	N. A.	Investigative	[1]
PNB-D-glucuronide	DMZ91P5	N. A.	N. A.	Investigative	[1]
------------------------------------------------------------------------------------

References

1	Active site flexibility revealed in crystal structures of Parabacteroides merdae beta-glucuronidase from the human gut microbiome. Protein Sci. 2018 Dec;27(12):2010-2022.