Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE69OXF)

DME Name	Beta-lactamase (blaB)
Synonyms	Penicillinase; Cephalosporinase; Beta-lactam; blaR1_1; CLOBL_05120
Gene Name	blaR1_1
UniProt ID	A0A1S8TSZ5_9CLOT
INTEDE ID	DME1336
EC Number	EC: 3.5.2.6 Hydrolases Carbon-nitrogen hydrolase Cyclic amide hydrolase EC: 3.5.2.6
Lineage	Species: Clostridium hiranonis Kingdom: Bacteria Phylum: Firmicutes Class: Clostridia Order: Clostridiales Family: Peptostreptococcaceae Genus: Clostridium Species: Clostridium hiranonis
Tissue Distribution	Primarily distributed in human gut.
Sequence	MFKKLVFLGILLLPLILWIIWSNTSKNSSNSSMIYVEKNNENSEKVLNEDLSKYFSGYDG CFVLYDKNENKYLIYNEAKSEKEISPCSTFKIVNALIGLDTNVLQDENTIFKWNGTKYAI EEWNKDQTLSSAVANSVVWYFQDVASKVGEERMQEYLSKIDYGNKDISGGLTKFWLQSSL KISPMQQVEILRNMYDYKLPFSRRNIDIVKKVLKISEQNGIVLSGKTGSGTDGNKSINGW FIGYVESDNDVFFLAVNIEGKDNATGVLAEQIAKNILKDKNIL
Function	This enzyme hydrolyzes beta-lactam.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ceftiofur	DMR2SOZ	Bacterial infection	1A00-1C4Z	Approved	[1]
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References

1	Bovine intestinal bacteria inactivate and degrade ceftiofur and ceftriaxone with multiple beta-lactamases. Antimicrob Agents Chemother. 2011 Nov;55(11):4990-8.