Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE7WRSB)

DME Name	Sulfatase (sulF)
Synonyms	Dehydroepiandrosterone sulfatase; Sulfate sulfatase; Cholesterol sulfate sulfohydrolase; Arylsufatase; Arylsulfatase C; AtsA; ASC; DDZ04_02500
Gene Name	DDZ04_02500
UniProt ID	A0A354WVI8_9BACT
INTEDE ID	DME1911
EC Number	EC: 3.1.6.1 Hydrolases Ester bond hydrolase Sulfuric ester hydrolase EC: 3.1.6.1
Lineage	Species: Parabacteroides johnsonii Kingdom: Bacteria Phylum: Bacteroidetes Class: Bacteroidia Order: Bacteroidales Family: Tannerellaceae Genus: Parabacteroides Species: Parabacteroides johnsonii
Tissue Distribution	Primarily distributed in human gut.
Sequence	MKKKVLFLILNYFAWLPLFVIQKPWFMTYNHPSAGNISLKDGWEVILHGLKLDCTVAGYL TVIPLLMTLISIWVTGKWYKKGIYAYTVMALLAITAIFSVDVALYAFWGFRIDSTLLFYL QSPKDALASIPARLFLQQTTSFLIYSTLGYLYLKRIIINHVPVEPVSNKVGATFAIIIVG AILFIPIRGGVTTSTANVGMVYFSQNQFLNHAAINPCFSLLSSLSKQEDFSKQFNFFDEK ERQDNIESLLSPVTSSDTTRILLKTRTPDILIIILESFSANVVEITGGLPDITPHLNQLG KEGVLFSHVYANSFRTDRGLVAILNGYPAQPTTSIMKYPAKSQTLPSIASSLRKAGYRSD MLYGGDINFTNMQSYFFSSGYSQITSDVDFPISDRLSKWGANDDVTFRFLLDHLKGREKE KAPWMTTFLTLSSHEPFEVPYHRFSHPYLNSVAFTDSCLGNFISRLKQSEIWDNLLIVLV ADHGFRYPEQLKDYEPDRFHIPMIWSGGAINKPAEINTICNQTDLAATLLGQLGISHQEY SFSKNILSPHRCDYSFYTFNNGFAFADSLGRYTIYDNESNRVLMEDAGNTMDRLQKGKAL LQTLYDDLGNR
Function	This enzyme catalyzes the hydrolysis of sulfate esters.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
[3H]estrone-3-sulphate	DMGPF0N	Discovery agent	N.A.	Investigative	[1]
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References

1	Parabacteroides pacaensis sp. nov. and Parabacteroides provencensis sp. nov., two new species identified from human gut microbiota. New Microbes New Infect. 2020 Jan 7;34:100642.