Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE8J31V)

• DME Name: Beta-galactosidase (bgaB)
• Synonyms: Beta-galactosidase/glucuronidase; Beta-galactosidase BgaBeta; Beta-Gal II; Beta-gal; EWR19_03520
• Gene Name: bgaB
• UniProt ID: A0A4Q7IW92_WEIPA
• INTEDE ID: DME1728
• Gene ID: 42681659
• EC Number:
  EC: 3.2.1.23
  Hydrolases
  Glycosylase
  O/S-glycosyl compound glycosidase
  EC: 3.2.1.23
• Lineage:
  Species: Weissella paramesenteroides
  Kingdom: Bacteria
  Phylum: Firmicutes
  Class: Bacilli
  Order: Lactobacillales
  Family: Leuconostocaceae
  Genus: Weissella
  Species: Weissella paramesenteroides
• Tissue Distribution: Primarily distributed in human gut.
• Sequence:
  MTAKLEWLDDPTVFRVGKLPAHSDHKVYRSAAEVVQGESSLISSLDGTWRFHFAKTPAER
  LINFEELNFNTENFDDIQVPGHIELQNFGQIQYINTLYPWEGKTYRRPPYALGADKTYPG
  IFSEASDNTVGQYVKTFTLPDNFNSHDVHIQFDGVEEAMYVWLNGQFVGYSEDSFSRAEF
  DLTPYLVNGENKLAVEVFKYSTAAFIEDQDMFRFSGIFRSVNLVAIPQVNVVDVHLKPVV
  SDDLRSGNLAIALTLAGELSDTTAQIIVNNPRGEAVLERTVTAEQTIQINESIENIALWS
  HKQPDLYELTVTIFDSDKQVIAVVPYAFGFRRLVKDANNHVTINGVPLHLNGVNRHEWSA
  VGGRSVTLDEMKTDIEIFKENNINAVRTSHYPNQIPWYGMCDEAGIYMMAETNLESHGTW
  QKMGAVEPSYNVPGSIPQWLDVVLDRAKSNFEQFKNHPSILFWSLGNESYTGDNLVAMDE
  YFKSVDDSRLTHYEGIFQNRVDEDRMSDVESRMYASPADIQEYLSNNPKKPYLNCEYMHS
  MGNSVGGFDEYVHLYDEFDTYLGGFIWDYIDQALYVTDEVTGKQVLRYGGDFDERHSDYE
  FSGDGIVFANRQPKPAIQEVSYYYGRYDN
• Function: This enzyme hydrolyzes alpha-L-arabinoside and beta-D-fucosides and beta-D-glucosides.
• KEGG Pathway:
  Galactose metabolism (wpa00052)
  Metabolic pathways (wpa01100)
  Other glycan degradation (wpa00511)
  Sphingolipid metabolism (wpa00600)

Molecular Interaction Atlas (MIA) of This DME

1 Clinical Trial Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
LS-69767	DM8VBQJ	N. A.	N. A.	Phase 1	[1]

References

• [1] In vitro fermentation of fructooligosaccharides with human gut bacteria. Food Funct. 2015 Mar;6(3):947-54.