Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE8KH4C)

• DME Name: Beta-lactamase (blaB)
• Synonyms: Penicillinase; Cephalosporinase; Beta-lactam; blaCARB; DBX26_23310
• Gene Name: blaCARB
• UniProt ID: A0A3B7D7C4_9VIBR
• INTEDE ID: DME2031
• EC Number:
  EC: 3.5.2.6
  Hydrolases
  Carbon-nitrogen hydrolase
  Cyclic amide hydrolase
  EC: 3.5.2.6
• Lineage:
  Species: Vibrio vulnificus
  Kingdom: Bacteria
  Phylum: Proteobacteria
  Class: Gammaproteobacteria
  Order: Vibrionales
  Family: Vibrionaceae
  Genus: Vibrio
  Species: Vibrio vulnificus
• Tissue Distribution: Primarily distributed in human gut.
• Sequence:
  MKKLLFLLALMVASPLSHASKLHEDVSLLEQQISGRIGIAVWDTQTDKHWAYRGDERFPL
  VGTFKTLACATMLSEMDTGILKKNATATVEKRDMVMWSPIMDKLAGQNVRIEHACEAAML
  MNDNTATNLVLSEIGGPKSVMLFLRTIGDKATRLDSAEPSVNEAMPGDKHDTTTPNAMVN
  TLETLIDGDALSYESRIQLKIWMQDSKVSDPLMRSVLPSGWSIADRSGAGGNGSLGFNAI
  IWKENHKPVYISIYLAETELSLQAREQLIAQISQLILYKYRNI
• Function: This enzyme hydrolyzes beta-lactam.

Molecular Interaction Atlas (MIA) of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Imipenem	DMI9FBP	Bacteremia	1A73	Approved	[1]

References

• [1] Carbapenemase VCC-1-producing Vibrio cholerae in coastal waters of Germany. Emerg Infect Dis. 2017 Oct;23(10):1735-1737.