Details of Drug-Metabolizing Enzyme (DME)
General Information of Drug-Metabolizing Enzyme (DME) (ID: DE8UGTM)
| DME Name | Aldehyde oxidase (AOX) | ||||
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| Synonyms | Aldehyde oxidase/xanthine dehydrogenase; Xanthine dehydrogenase molybdopterin-binding; NCTC534_00123; VT96_0232590; xdhAC | ||||
| Gene Name | xdhAC | ||||
| UniProt ID | |||||
| INTEDE ID | |||||
| EC Number | EC: 1.17.1.4 | ||||
| Lineage | Species: Clostridium sporogenes | ||||
| Tissue Distribution | Primarily distributed in human gut. | ||||
| Sequence |
MYEFILNGRNVSVSEDMNLLEYLRDHEDLTSVKNGCAEGACGACMILLDGKAVRACINTT
AKVHGKDIKTVEGLTEFEKKVFTWAFSKAGAVQCGFCIPGMIISAKALLDKNLNPNKKEI KTAIRGNVCRCTGYVKIIKAIEMAAEAFRDGKLILNEEYKGKIGENIPRIDARDKILGIG KYVDDMKVEGMIYGSALRIKYPRALVKSIDISEALKHPDVETIITAKDIPGNRYIGHIIK DWPAMIDVGEETRYVGDSVALVAAKNKKALKEILNLIKVEYEELEPISNPDMAMDEDAPK IHPKGNVLTVEKVNRGDVDEAIANSKYVVSNHYSTPFTEHAFLELESALAMPDEDGVIIY TGSQGIYDEQREISELLGLPKEKVRTISKYVGGGFGGKEDMSVQHHAALLAWIIKKPVKV TLSRKESIKIHPKRHAMEMTITTACDEKGNLTAFKADIVADTGAYASLGGPVLQRACTHA AGPYKCPNVKIKGTAVYTNNPPGGAFRGFGVTQSVFASECNLNLLAQKVGISPWEIRFKN AVEPGDALPNGQIADKGTAIKETILAVKDIYENNKYVGIACCMKNSGVGVGLPDIGRCNL VVIKGKVHIRTSAACIGQGLGTILIQIICETTDLLPEQIILDLPDTKFAPNSGTTTASRQ TVFTGEATRIASLKLKDKLLTTSLEECEGEEFYGEYQGITDPINSDKKNPVSHVAYGYAT QVVILNDDGKVEKVVAAHDVGKAINSTNVEGQIEGGIVMGLGYAFTEDYPLNKSIPTAKF GTLGLFRATDIPEIQPIIIEKNTNDLAYGAKGIGEITTIPTAPAAQGAYYKFDGEFRKKL PLKDTAYRRKK |
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| Function | This enzyme acts on a variety of purines and aldehydes, including hypoxanthine. | ||||
Molecular Interaction Atlas (MIA) of This DME
| Molecular Interaction Atlas (MIA) | ||||||||||||||||||||||||||||
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1 Approved Drug(s) Metabolized by This DME
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