Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE9EXRN)

DME Name	Beta-glucuronidase (uidA)
Synonyms	Beta-galactosidase/beta-glucuronidase; Beta-galactosidase BgaB; ERS852582_00799; uidA
Gene Name	uidA
UniProt ID	A0A173S5S4_9FIRM
INTEDE ID	DME1210
EC Number	EC: 3.2.1.31 Hydrolases Glycosylase O/S-glycosyl compound glycosidase EC: 3.2.1.31
Lineage	Species: Faecalibacterium prausnitzii Kingdom: Bacteria Phylum: Firmicutes Class: Clostridia Order: Clostridiales Family: Ruminococcaceae Genus: Faecalibacterium Species: Faecalibacterium prausnitzii
Tissue Distribution	Primarily distributed in human gut.
Sequence	MRSIAKLMKDWQFTGPDGVTAAVALPHTWNAVDGQDGGNDYWRGTCIYRTSFAAPAFDPA QQQVWLQFEGVNSSAAVLLNGQQLCTHDGGYSTFRAEITELLQAENQLTVRVDNSVNDRV YPQKADFTFYGGIYRDVSLLVVNKNHIALGHFGDTGVKITPDLKEGSADIQVETLVEGEG TVVVELLDAEGNSVARSEGAKASLHLDAPHLWNGVKDPYLYTCIVRLMQDGKPVDEVTTR VGLRSFSVDAKKGFFLNGKPYPLHGVSRHQDRKGLGNAITREMHDEDMALIRELGANTVR LAHYQHDQYFYDLCDKYGMVVWAEIPYISEHLPKGRENTISQMKELIHQNYNHPSIVCWG VSNEITISTKDKADMLDNHRVLNELCHKMDPTRLTTLACYAMCGPFNSVAHITDLVSWNL YLGWYVPGLFLNDLWMGFFHLVYPNRPLGFSEYGAEGMPNLHSAHPRRGDHTEEYQAKYH EYMLKCFDRHPWLWATHVWNMFDFAADARDQGGEPGMNHKGLVTFDRKTKKDSFYLYKAW WSEENFVHICSKRFTDRTEKEIEVKVYSNQKSVTLYADGKKLAEQTGEHIFKFRVPLHGK VELKAVAGDCIDTACFRSVAAPNPSYKLVKTKSKSANWV
Function	This enzyme takes part in glucuronoside catabolic process. It catalyzes the hydrolysis of beta-glucuronide containing substrates.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

2 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diclofenac glucuronide	DMWADLM	N. A.	N. A.	Investigative	[1]
PhIP glucuronide	DM7DWZC	N. A.	N. A.	Investigative	[2]
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References

1	tructure, function, and inhibition of drug reactivating human gut microbial beta-glucuronidases. Sci Rep. 2019 Jan 29;9(1):825.
2	Gut microbial beta-glucuronidase and glycerol/diol dehydratase activity contribute to dietary heterocyclic amine biotransformation. BMC Microbiol. 2019 May 16;19(1):99.