Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DECB2MX)

DME Name	Beta-lactamase (blaB)
Synonyms	Penicillinase; Cephalosporinase; Beta-lactam; SAMN05421866_1863
Gene Name	blaB
UniProt ID	A0A1M5PLB6_9FLAO
INTEDE ID	DME2023
EC Number	EC: 3.5.2.6 Hydrolases Carbon-nitrogen hydrolase Cyclic amide hydrolase EC: 3.5.2.6
Lineage	Species: Chryseobacterium oranimense Kingdom: Bacteria Phylum: Bacteroidetes Class: Flavobacteriia Order: Flavobacteriales Family: Flavobacteriaceae Genus: Chryseobacterium Species: Chryseobacterium oranimense Subspecies: Chryseobacterium oranimense G311
Tissue Distribution	Primarily distributed in human gut.
Sequence	MNTRYLKIFSALVVIAIIFVARLSYLQLFTDRYALNAANTSIKIEYVIPQRGVVFDRNGK ILVGNQPAYEISFTQALMKPDFDTIGFCNLMQISKSDFIKRIEIIKKEKYYSKLTPMTFI KDLSREDIARVQEIIFKYPAFSIVSRPQRQYEVATSGNLLGYTSEVNEREIKKDSTYYLP GDFIGKTGVEKSYEKDLRGIKGMKYIQKDIKLRNIGSYKNGSLDKDVVTGKDITLTIDYD LQRIAEEMLVNKHGAIVAIDPNNGEILTLATGPDIDPNLFTGPNKSKNLYALSKDTLYEN KPTFDRSVQAAYPPGSTFKLLTALAGMQMGVMDENTVFPCGGGFFYKGLRIKGHGGADPL IPAIQVSSNCYFSHAFIAIMNKYPGDPSRGVNEWKKIMSSFGVGEYLNNDIAVGSPGRIP TGEFYEKRSGKKNWSSDYTMNGSIFNGMGQGDVLVTPLQLANYVAAIANKGWFYTPHIVK SIDGKPNPDPRFKTKHKTLVDPKHFEPVLKGMEAVVLRGTARSLKSSDFTQLAKTGTAQV PQGKDNSIFVLIAPADKPRIVVAAVMEHAGFGATWAGPACTVIAEKYITGDLKRENLYKK MTGASFMPEYKRQWIADLKRKGLYKDPTADSLKLKRKQDSLNFIKEQKAKLQKKIEEETK NNTKKIKK
Function	This enzyme hydrolyzes beta-lactam.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Imipenem	DMI9FBP	Bacteremia	1A73	Approved	[1]
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References

1	Whole-genome sequence of Chryseobacterium oranimense, a colistin-resistant bacterium isolated from a cystic fibrosis patient in France. Antimicrob Agents Chemother. 2015 Mar;59(3):1696-706.