Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DECW8T2)

• DME Name: Beta-glucuronidase (uidA)
• Synonyms: Beta-galactosidase/beta-glucuronidase; Beta-galactosidase BgaB; B5F00_14980; DWW04_15510; DXA69_19840; E1I72_12205; E1I98_19230; E1J02_10435; E1J03_18605; E1J06_16940; EAJ02_20045
• Gene Name: uidA
• UniProt ID: A0A076IX12_9BACE
• INTEDE ID: DME1352
• EC Number:
  EC: 3.2.1.31
  Hydrolases
  Glycosylase
  O/S-glycosyl compound glycosidase
  EC: 3.2.1.31
• Lineage:
  Species: Bacteroides dorei
  Kingdom: Bacteria
  Phylum: Bacteroidetes
  Class: Bacteroidia
  Order: Bacteroidales
  Family: Bacteroidaceae
  Genus: Bacteroides
  Species: Bacteroides dorei
• Tissue Distribution: Primarily distributed in human gut.
• Sequence:
  MKKTLLTICLTWMCFSLSAQKIIDLSGKWSFSIDRQDNGEKEKWFSHTLNDCINLPGSMP
  EKLKGDEVTAKTQWTGSLYDSSYYYNPYMEKYRKEGNIKFPFFLTPDKHYVGAAWYQKEV
  NIPADWKGERILLFLERPHIETTVWVNGQKTGMQNSLCVPHQYDITRYVRPGKCTITIRV
  DNRIKEINVGPDSHSITDQTQGNWNGIVGRICLQTTPKTYFDDIQIYPEPEQKLARVKVV
  IKGAGITKIKLSAESFNTDKKHIVPAIQQEIKLNKGVTETEMVLPMGNDMLLWDEFHPAL
  YKLKAEVTNGKKTEIKEIQFGMRRFEIKGKWFYVNGRKTQLRGTVENCDFPLTGYAPMDV
  ESWERVFRICRSYGLNHMRFHSFCPPEAAFIAADRVGFYLQPEGPSWPNHGPKLGLGQPI
  DTYLMNETIALTKEYGNYASYCMLACGNEPSGRWVEWVTKFVEYWEKKDPRHVYTGASVG
  NGWQWQPRNQYHVKAGARGLTWSRRQPSTQDDYRFQNHLDTVKQPYVSHETGQWCAFPNF
  NEIRKYTGVNKAKNFEIFKDILADNHMSDQAHLFMMASGKLQALCYKYEIEKTLRTPDYA
  GFQLLALNDYSGQGTALVGVLDVFFEEKGYINSAEWRRFCSPTVPLMRTDKFVYNNNEIL
  KADIEVAHFGAKTLKQAEIVYTLKDEYGKVYAQGTLATQDIPIGNLNHTGSLEFPLTDIQ
  EAKKLNLEIRITGTEAVNDWNFWVYPAQVTIAEGKVYTTDTLDSKALEILQHGGNVLITA
  AGKVSYGKEVVQQFTPVFWNTSWFKMRPPHTTGILVNPKHPLFRQFPTEYHSNLQWWELL
  NHAQVMQFTHFPPAFQPTVQSIDTWFISRKIGMLFEANVLNGKVLMTSMDITSQPEKRIV
  ARQMHKAILDYMNSDQFRPQFTVTPQQISELFTKTAGDIKSYTNDSPDELKPKIN
• Function: This enzyme takes part in glucuronoside catabolic process. It catalyzes the hydrolysis of beta-glucuronide containing substrates.

Molecular Interaction Atlas (MIA) of This DME

1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diclofenac glucuronide	DMWADLM	N. A.	N. A.	Investigative	[1]

References

• [1] tructure, function, and inhibition of drug reactivating human gut microbial beta-glucuronidases. Sci Rep. 2019 Jan 29;9(1):825.