Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DED6V8P)

DME Name	Oxygen-insensitive NADPH nitroreductase A (nfsA)
Synonyms	Oxygen-insensitive NAD(P)H nitroreductase A; Modulator of drug activity A; nfsA; pnrA
Gene Name	pnrA
UniProt ID	Q7B4Y3_PSEPU
INTEDE ID	DME1586
EC Number	EC: 1.5.1.38 Oxidoreductase CH-NH donor oxidoreductase NAD/NADP acceptor oxidoreductase EC: 1.5.1.38
Lineage	Species: Pseudomonas putida Kingdom: Bacteria Phylum: Proteobacteria Class: Gammaproteobacteria Order: Pseudomonadales Family: Pseudomonadaceae Genus: Pseudomonas Species: Pseudomonas putida Subspecies: Pseudomonas putida JLR11
Tissue Distribution	Primarily distributed in human skin.
Sequence	MSLQDEALKAWQARYGEPANLPAADTVIAQMLQHRSVRAYSDLPVDEQMLSWAIAAAQSA STSSNLQAWSVLAVRDRERLARLARLSGNQRHVEQAPLFLVWLVDWSRLRRLARTLQAPT AGIDYLESYTVGVVDAALAAQNAALAFEAQGLGIVYIGGMRNHPEAMSEELGLPNDTFAV FGMCVGHPDPAQPAEIKPRLAQSVVLHRERYEATEAEAVSVAAYDRRMSDFQHRQQRENR SWSSQAVERVKGADSLSGRHRLRDALNTLGFGLR
Function	This enzyme can catalyze FMN and also can catalyze FAD and riboflavin with lower activity.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitrobenzoate	DM6FVHC	Discovery agent	N.A.	Investigative	[1], [2]
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References

1	PnrA, a new nitroreductase-family enzyme in the TNT-degrading strain Pseudomonas putida JLR11. Environ Microbiol. 2005 Aug;7(8):1211-9.
2	A Lethal Case of Pseudomonas putida Bacteremia Due to Soft Tissue Infection. Infect Dis Clin Pract (Baltim Md). 2013 May;21(3):147-213.