Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEDG68B)

DME Name Sulfurylase kinase 1 (PAPSS1)
Synonyms
Sulfate adenylate transferase; Sulfate adenylyltransferase; PAPS synthase 1; 3'-phosphoadenosine-5'-phosphosulfate synthase; APS kinase; ATP-sulfurylase; ATPSK1; Adenosine-5'-phosphosulfate 3'-phosphotransferase; Adenylyl-sulfate kinase; Adenylylsulfate 3'-phosphotransferase; Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1; PAPSS; PAPSS 1; PAPSS1; SAT
Gene Name PAPSS1
UniProt ID
PAPS1_HUMAN
INTEDE ID
DME0455
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Gene ID
9061
EC Number EC: 2.7.7.4
Transferase
Kinase
Nucleotidyltransferase
EC: 2.7.7.4
Lineage Species: Homo sapiens
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Sequence
MEIPGSLCKKVKLSNNAQNWGMQRATNVTYQAHHVSRNKRGQVVGTRGGFRGCTVWLTGL
SGAGKTTVSMALEEYLVCHGIPCYTLDGDNIRQGLNKNLGFSPEDREENVRRIAEVAKLF
ADAGLVCITSFISPYTQDRNNARQIHEGASLPFFEVFVDAPLHVCEQRDVKGLYKKARAG
EIKGFTGIDSEYEKPEAPELVLKTDSCDVNDCVQQVVELLQERDIVPVDASYEVKELYVP
ENKLHLAKTDAETLPALKINKVDMQWVQVLAEGWATPLNGFMREREYLQCLHFDCLLDGG
VINLSVPIVLTATHEDKERLDGCTAFALMYEGRRVAILRNPEFFEHRKEERCARQWGTTC
KNHPYIKMVMEQGDWLIGGDLQVLDRVYWNDGLDQYRLTPTELKQKFKDMNADAVFAFQL
RNPVHNGHALLMQDTHKQLLERGYRRPVLLLHPLGGWTKDDDVPLMWRMKQHAAVLEEGV
LNPETTVVAIFPSPMMYAGPTEVQWHCRARMVAGANFYIVGRDPAGMPHPETGKDLYEPS
HGAKVLTMAPGLITLEIVPFRVAAYNKKKKRMDYYDSEHHEDFEFISGTRMRKLAREGQK
PPEGFMAPKAWTVLTEYYKSLEKA
Function
This enzyme is with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase).
KEGG Pathway
Metabolic pathways (hsa01100 )
Purine metabolism (hsa00230 )
Selenocompound metabolism (hsa00450 )
Sulfur metabolism (hsa00920 )
Reactome Pathway
Signaling by BRAF and RAF fusions (R-HSA-6802952 )
Transport and synthesis of PAPS (R-HSA-174362 )
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se (R-HSA-2408550 )

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DME
2 Investigative Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
Adenylylsulfate DM0YQ2I N. A. N. A. Investigative [1]
SULFATE DMW0ZBF Discovery agent N.A. Investigative [1]
Experimental Enzyme Kinetic Data of Drugs
Drug Name Indication Highest Status Kinetic Data REF
SULFATE Discovery agent [N.A.] Investigative Km = 0.16 microM [1]

Molecular Expression Atlas (MEA) of This DME

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DME
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Acute myelocytic leukaemia 2B33.1 Bone marrow 2.86E-02 2.35E-02 5.34E-02
Alopecia ED70 Skin from scalp 1.69E-03 -1.41E-01 -5.15E-01
Alzheimer's disease 8A20 Entorhinal cortex 4.59E-02 -4.06E-02 -1.69E-01
Ankylosing spondylitis FA92.0 Pheripheral blood 4.66E-01 -7.36E-02 -2.87E-01
Aortic stenosis BB70 Calcified aortic valve 8.92E-01 9.39E-02 7.91E-02
Apnea 7A40 Hyperplastic tonsil 2.50E-01 2.92E-01 7.35E-01
Arthropathy FA00-FA5Z Peripheral blood 4.54E-01 1.62E-01 4.10E-01
Asthma CA23 Nasal and bronchial airway 5.33E-02 -4.86E-01 -5.55E-01
Atopic dermatitis EA80 Skin 1.36E-04 -2.03E-01 -1.64E+00
Autism 6A02 Whole blood 1.03E-02 2.98E-01 7.63E-01
Autoimmune uveitis 9A96 Peripheral monocyte 4.30E-01 1.78E-01 3.79E-01
Autosomal dominant monocytopenia 4B04 Whole blood 2.62E-03 1.47E+00 2.01E+00
Bacterial infection of gingival 1C1H Gingival tissue 2.61E-01 5.92E-02 2.89E-01
Batten disease 5C56.1 Whole blood 1.32E-01 -2.53E-01 -1.30E+00
Behcet's disease 4A62 Peripheral blood 9.56E-01 8.80E-02 1.62E-01
Bipolar disorder 6A60-6A6Z Prefrontal cortex 5.80E-01 4.36E-02 1.87E-01
Bladder cancer 2C94 Bladder tissue 4.70E-02 -2.46E-01 -1.12E+00
Breast cancer 2C60-2C6Z Breast tissue 1.43E-01 -1.63E-01 -3.60E-01
Cardioembolic stroke 8B11.20 Whole blood 1.01E-04 5.10E-01 1.21E+00
Cervical cancer 2C77 Cervical tissue 4.96E-03 -3.60E-01 -8.54E-01
Childhood onset rheumatic disease FA20.Z Peripheral blood 1.07E-01 2.75E-01 3.91E-01
Chronic hepatitis C 1E51.1 Whole blood 1.44E-01 -2.05E-01 -4.89E-01
Chronic obstructive pulmonary disease CA22 Lung tissue 8.55E-02 -1.66E-01 -5.28E-01
Chronic obstructive pulmonary disease CA22 Small airway epithelium 3.13E-02 -8.15E-02 -2.26E-01
Chronic rhinosinusitis CA0A Sinus mucosa tissue 4.57E-01 -1.50E-01 -3.34E-01
Colon cancer 2B90 Colon tissue 1.71E-29 5.19E-01 1.25E+00
Coronary artery disease BA80-BA8Z Peripheral blood 7.23E-01 -1.92E-01 -2.46E-01
Diffuse large B-cell lymphoma 2A81 Tonsil tissue 7.91E-01 -5.26E-02 -7.05E-02
Endometriosis GA10 Endometrium tissue 3.07E-02 -1.13E+00 -1.14E+00
Familial hypercholesterolemia 5C80.00 Peripheral blood 3.79E-01 1.59E-01 5.32E-01
Familial hypercholesterolemia 5C80.00 Whole blood 1.32E-10 9.89E-01 2.04E+00
Gastric cancer 2B72 Gastric tissue 2.80E-01 -8.07E-01 -1.29E+00
Glioblastopma 2A00.00 Nervous tissue 1.18E-25 -3.71E-01 -9.95E-01
Glioma 2A00.0Y-2A00.0Z Brain stem tissue 1.43E-01 2.99E-01 1.97E+00
Glioma 2A00.0Y-2A00.0Z White matter tissue 2.64E-04 1.11E+00 1.65E+00
Head and neck cancer 2D42 Head and neck tissue 8.46E-12 -4.60E-01 -1.01E+00
HIV-associated neurocognitive impairment 8A2Y-8A2Z White matter tissue 5.20E-01 9.59E-02 2.73E-01
Huntington's disease 8A01.10 Whole blood 9.79E-01 -2.98E-03 -8.33E-03
Idiopathic pulmonary fibrosis CB03.4 Lung tissue 2.13E-01 6.31E-01 1.20E+00
Immunodeficiency 4A00-4A20 Peripheral blood 6.11E-01 -1.34E-01 -5.10E-01
Influenza 1E30 Whole blood 7.03E-01 -3.71E-01 -3.55E-01
Interstitial cystitis GC00.3 Bladder tissue 5.84E-02 -8.46E-02 -1.59E+00
Intracranial aneurysm 8B01.0 Intracranial artery 1.00E-05 7.52E-01 2.22E+00
Irritable bowel syndrome DD91.0 Rectal colon tissue 9.99E-01 -1.42E-02 -5.15E-02
Ischemic stroke 8B11 Peripheral blood 9.98E-01 6.56E-02 2.85E-01
Juvenile idiopathic arthritis FA24 Peripheral blood 3.14E-01 8.39E-02 1.67E-01
Lateral sclerosis 8B60.4 Skin 3.86E-01 -1.06E-01 -6.01E-01
Lateral sclerosis 8B60.4 Cervical spinal cord 1.20E-01 -4.81E-01 -8.28E-01
Liver cancer 2C12.0 Liver tissue 1.61E-26 1.02E+00 2.74E+00
Liver failure DB99.7-DB99.8 Liver tissue 2.23E-04 8.24E-01 2.09E+00
Lung cancer 2C25 Lung tissue 1.98E-51 -5.80E-01 -1.61E+00
Lupus erythematosus 4A40 Whole blood 7.38E-01 -3.59E-02 -5.67E-02
Major depressive disorder 6A70-6A7Z Hippocampus 8.56E-01 -1.23E-02 -5.29E-02
Major depressive disorder 6A70-6A7Z Whole blood 9.67E-01 5.25E-03 1.33E-02
Melanoma 2C30 Skin 4.25E-01 2.12E-01 2.79E-01
Multiple myeloma 2A83.1 Peripheral blood 2.20E-01 -1.29E-01 -3.25E-01
Multiple myeloma 2A83.1 Bone marrow 9.06E-04 8.83E-01 2.08E+00
Multiple sclerosis 8A40 Plasmacytoid dendritic cells 2.50E-01 -2.21E-02 -1.12E-01
Myelodysplastic syndrome 2A36-2A3Z Bone marrow 5.71E-01 6.38E-02 1.28E-01
Myelofibrosis 2A20.2 Whole blood 5.76E-01 4.86E-02 2.15E-01
Myocardial infarction BA41-BA50 Peripheral blood 5.63E-01 1.99E-01 3.26E-01
Myopathy 8C70.6 Muscle tissue 4.39E-06 7.00E-01 2.56E+00
Neonatal sepsis KA60 Whole blood 1.32E-27 7.87E-01 2.08E+00
Neuroectodermal tumour 2A00.11 Brain stem tissue 9.93E-05 -6.58E-01 -2.81E+00
Non-alcoholic fatty liver disease DB92 Liver tissue 7.35E-01 6.60E-02 1.51E-01
Obesity related type 2 diabetes 5A11 Omental adipose tissue 1.24E-01 -1.43E-01 -4.01E-01
Olive pollen allergy CA08.00 Peripheral blood 7.29E-01 -3.90E-02 -1.83E-01
Oral cancer 2B6E Oral tissue 2.91E-01 1.42E-01 2.85E-01
Osteoarthritis FA00-FA0Z Synovial tissue 3.34E-01 4.84E-01 4.53E-01
Osteoporosis FB83.1 Bone marrow 6.14E-02 -1.72E-01 -1.74E+00
Ovarian cancer 2C73 Ovarian tissue 3.65E-02 3.47E-01 7.99E-01
Pancreatic cancer 2C10 Pancreas 4.85E-03 2.94E-01 8.15E-01
Parkinson's disease 8A00.0 Substantia nigra tissue 4.59E-01 1.06E-01 2.77E-01
Pediatric respiratory syncytial virus infection CA40.11 Peripheral blood 2.30E-03 1.72E-01 8.09E-01
Pituitary cancer 2D12 Pituitary tissue 2.09E-03 5.65E-01 1.93E+00
Pituitary gonadotrope tumour 2D12 Pituitary tissue 1.29E-03 5.85E-01 2.04E+00
Polycystic ovary syndrome 5A80.1 Vastus lateralis muscle 5.24E-03 2.39E-01 1.63E+00
Polycythemia vera 2A20.4 Whole blood 2.50E-02 2.32E-01 9.11E-01
Pompe disease 5C51.3 Biceps muscle 4.36E-03 4.20E-01 1.07E+00
Preterm birth KA21.4Z Myometrium 6.70E-01 1.65E-01 2.13E-01
Prostate cancer 2C82 Prostate 6.67E-02 -5.10E-01 -6.51E-01
Psoriasis EA90 Skin 3.41E-21 -2.62E-01 -1.06E+00
Rectal cancer 2B92 Rectal colon tissue 7.01E-01 -3.07E-01 -5.80E-01
Renal cancer 2C90-2C91 Kidney 1.27E-02 -3.21E-01 -8.95E-01
Retinoblastoma 2D02.2 Uvea 3.80E-03 3.07E-01 2.06E+00
Rheumatoid arthritis FA20 Synovial tissue 1.23E-03 8.69E-01 1.67E+00
Rhinovirus infection CA42.1 Nasal epithelium tissue 4.24E-01 5.14E-03 3.62E-02
Schizophrenia 6A20 Prefrontal cortex 2.11E-01 -6.52E-02 -1.57E-01
Schizophrenia 6A20 Superior temporal cortex 3.00E-01 -1.48E-02 -6.73E-02
Scleroderma 4A42.Z Whole blood 7.55E-03 -4.02E-01 -1.37E+00
Seizure 8A60-8A6Z Whole blood 1.07E-01 -1.02E-01 -3.59E-01
Sensitive skin EK0Z Skin 5.01E-01 3.73E-02 3.31E-01
Sepsis with septic shock 1G41 Whole blood 6.70E-43 7.48E-01 1.84E+00
Shwachman-Diamond syndrome 3A70.0 Bone marrow 2.22E-01 -1.22E-01 -4.45E-01
Sickle cell disease 3A51.0-3A51.3 Peripheral blood 7.13E-01 3.97E-01 4.83E-01
Simpson golabi behmel syndrome LD2C Adipose tissue 2.30E-01 -3.96E-01 -1.72E+00
Sjogren's syndrome 4A43.2 Salivary gland tissue 3.45E-01 -5.51E-02 -3.91E-01
Skin cancer 2C30-2C3Z Skin 4.45E-17 -4.93E-01 -9.63E-01
Thrombocythemia 3B63 Whole blood 1.10E-01 -1.24E-01 -5.31E-01
Thrombocytopenia 3B64 Whole blood 1.72E-01 -6.42E-01 -8.35E-01
Thyroid cancer 2D10 Thyroid 1.89E-28 5.04E-01 1.41E+00
Tibial muscular dystrophy 8C75 Muscle tissue 3.60E-08 1.15E+00 2.52E+00
Tuberous sclerosis complex LD2D.2 Perituberal tissue 1.80E-01 -1.28E-01 -8.76E-01
Type 2 diabetes 5A11 Liver tissue 8.11E-01 2.15E-01 3.34E-01
Ureter cancer 2C92 Urothelium 8.63E-01 5.29E-02 1.14E-01
Uterine cancer 2C78 Endometrium tissue 1.69E-17 -1.18E+00 -1.03E+00
Vitiligo ED63.0 Skin 1.62E-04 3.07E-01 2.89E+00
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⏷ Show the Full List of DME Expression Under 107 Diseases

References

1 Human 3'-phosphoadenosine 5'-phosphosulfate synthetase (isoform 1, brain): kinetic properties of the adenosine triphosphate sulfurylase and adenosine 5'-phosphosulfate kinase domains. Biochemistry. 2004 Apr 13;43(14):4356-65.