Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEDZECR)

• DME Name: Glycosyl hydrolase (glyH)
• Synonyms: Glycosidase; Glycoside hydrolase; Furcatin hydrolase; Isoflavonoid 7-O-apiosylglucosidase; BF0853; bglB
• Gene Name: glyH
• UniProt ID: G1091_BACFN
• INTEDE ID: DME1723
• EC Number:
  EC: 3.2.1.18
  Hydrolases
  Glycosylase
  O/S-glycosyl compound glycosidase
  EC: 3.2.1.18
• Lineage:
  Species: Bacteroides fragilis
  Kingdom: Bacteria
  Phylum: Bacteroidetes
  Class: Bacteroidia
  Order: Bacteroidales
  Family: Bacteroidaceae
  Genus: Bacteroides
  Species: Bacteroides fragilis
• Tissue Distribution: Primarily distributed in human gut.
• Sequence:
  MFKHLNALFIGLALFACTSGAVAQTIKPIETPVPVRPAGQKDVVGLTTPKLDVVRVGFIG
  LGMRGPGAVERFTHIPGTQIVALCDLIPERVAGAQKILTKANLPEAASYSGSEDAWKKLC
  ERKDIDLVYIATDWKHHAQMAIYAMEHGKHVAIEVPSAMTLDEIWALINTSEKTRKHCMQ
  LENCVYDFFELTTLNMAQQGVFGEVLHTEGAYIHNLEDFWPYYWNNWRMDYNQNHRGDVY
  ATHGMGPACQLLDIHRGDKMNYLVSMDTKAVNGPAYIKKTTGKEVKDFQNGDQTSTLIRT
  EKGKTILIQHNVMTPRPYSRMYQVVGADGYASKYPIEEYCMRPTQIASNDVPNHEKLNAH
  GSVPADVKKALMDKYKHPIHKELEETAKKVGGHGGMDYIMDYRLVYCLRNGLPLDMDVYD
  LAEWCCMADLTKLSIENSSAPVAIPDFTRGAWNKVKGYRHAFAK
• Function: This enzyme does not act on 4-O-acetylated sialic acids and it has no alpha-N-acetylgalactosaminidase activity.

Molecular Interaction Atlas (MIA) of This DME

1 Clinical Trial Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
LS-69767	DM8VBQJ	N. A.	N. A.	Phase 1	[1]

References

• [1] In vitro fermentation of fructooligosaccharides with human gut bacteria. Food Funct. 2015 Mar;6(3):947-54.