Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEE76VW)

DME Name Acetyl-CoA synthetase (ACSS2)
Synonyms
Acetate--CoA ligase; Acetyl-CoA synthetase 1; Acetyl-coenzyme A synthetase, cytoplasmic; Acyl-CoA synthetase short-chain family member 2; Acyl-activating enzyme; Propionate--CoA ligase; ACAS2; ACS; ACSS2; AceCS; AceCS1
Gene Name ACSS2
UniProt ID
ACSA_HUMAN
INTEDE ID
DME0212
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Gene ID
55902
EC Number EC: 6.2.1.1
Ligase
Carbon-sulfur ligase
Acid-thiol ligase
EC: 6.2.1.1
Lineage Species: Homo sapiens
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Sequence
MGLPEERVRSGSGSRGQEEAGAGGRARSWSPPPEVSRSAHVPSLQRYRELHRRSVEEPRE
FWGDIAKEFYWKTPCPGPFLRYNFDVTKGKIFIEWMKGATTNICYNVLDRNVHEKKLGDK
VAFYWEGNEPGETTQITYHQLLVQVCQFSNVLRKQGIQKGDRVAIYMPMIPELVVAMLAC
ARIGALHSIVFAGFSSESLCERILDSSCSLLITTDAFYRGEKLVNLKELADEALQKCQEK
GFPVRCCIVVKHLGRAELGMGDSTSQSPPIKRSCPDVQISWNQGIDLWWHELMQEAGDEC
EPEWCDAEDPLFILYTSGSTGKPKGVVHTVGGYMLYVATTFKYVFDFHAEDVFWCTADIG
WITGHSYVTYGPLANGATSVLFEGIPTYPDVNRLWSIVDKYKVTKFYTAPTAIRLLMKFG
DEPVTKHSRASLQVLGTVGEPINPEAWLWYHRVVGAQRCPIVDTFWQTETGGHMLTPLPG
ATPMKPGSATFPFFGVAPAILNESGEELEGEAEGYLVFKQPWPGIMRTVYGNHERFETTY
FKKFPGYYVTGDGCQRDQDGYYWITGRIDDMLNVSGHLLSTAEVESALVEHEAVAEAAVV
GHPHPVKGECLYCFVTLCDGHTFSPKLTEELKKQIREKIGPIATPDYIQNAPGLPKTRSG
KIMRRVLRKIAQNDHDLGDMSTVADPSVISHLFSHRCLTIQ
Function This enzyme catalyzes the synthesis of acetyl-CoA from short-chain fatty acids. Acetate is the preferred substrate. And it can also utilize propionate with a much lower affinity.
KEGG Pathway
Carbon metabolism (hsa01200 )
Glycolysis / Gluconeogenesis (hsa00010 )
Glyoxylate and dicarboxylate metabolism (hsa00630 )
Metabolic pathways (hsa01100 )
Propanoate metabolism (hsa00640 )
Pyruvate metabolism (hsa00620 )
Reactome Pathway
Transcriptional activation of mitochondrial biogenesis (R-HSA-2151201 )
Ethanol oxidation (R-HSA-71384 )

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DME
1 Approved Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sodium Acetate Anhydrous DMH21E0 Hyponatraemia 5C72 Approved [1]

Molecular Expression Atlas (MEA) of This DME

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DME
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Acute myelocytic leukaemia 2B33.1 Bone marrow 2.53E-10 2.36E-01 7.83E-01
Alopecia ED70 Skin from scalp 3.36E-04 3.15E-01 6.56E-01
Alzheimer's disease 8A20 Entorhinal cortex 6.06E-04 1.42E-01 4.42E-01
Ankylosing spondylitis FA92.0 Pheripheral blood 6.15E-02 2.03E-01 5.02E-01
Aortic stenosis BB70 Calcified aortic valve 2.54E-01 -1.69E-01 -3.53E-01
Apnea 7A40 Hyperplastic tonsil 4.50E-01 -6.50E-02 -3.13E-01
Arthropathy FA00-FA5Z Peripheral blood 7.59E-02 2.09E-01 7.49E-01
Asthma CA23 Nasal and bronchial airway 1.09E-06 3.84E-01 5.48E-01
Atopic dermatitis EA80 Skin 3.41E-01 -1.21E-01 -2.86E-01
Autism 6A02 Whole blood 5.46E-02 1.50E-01 5.56E-01
Autoimmune uveitis 9A96 Peripheral monocyte 2.44E-01 4.85E-02 1.95E-01
Autosomal dominant monocytopenia 4B04 Whole blood 3.80E-01 2.38E-01 5.63E-01
Bacterial infection of gingival 1C1H Gingival tissue 8.04E-01 1.12E-02 4.88E-02
Batten disease 5C56.1 Whole blood 4.56E-01 1.95E-01 1.69E+00
Behcet's disease 4A62 Peripheral blood 8.77E-01 1.31E-03 1.09E-02
Bipolar disorder 6A60-6A6Z Prefrontal cortex 6.85E-01 -1.89E-02 -1.49E-01
Bladder cancer 2C94 Bladder tissue 1.30E-01 3.45E-01 7.50E-01
Breast cancer 2C60-2C6Z Breast tissue 1.40E-86 -1.26E+00 -1.68E+00
Cardioembolic stroke 8B11.20 Whole blood 1.20E-07 3.77E-01 1.44E+00
Cervical cancer 2C77 Cervical tissue 5.94E-03 -1.24E-01 -5.39E-01
Childhood onset rheumatic disease FA20.Z Peripheral blood 9.38E-01 1.85E-01 3.00E-01
Chronic hepatitis C 1E51.1 Whole blood 9.21E-01 -1.61E-02 -4.08E-02
Chronic obstructive pulmonary disease CA22 Lung tissue 4.27E-01 -2.40E-02 -8.97E-02
Chronic obstructive pulmonary disease CA22 Small airway epithelium 4.87E-01 -1.46E-02 -5.61E-02
Chronic rhinosinusitis CA0A Sinus mucosa tissue 3.20E-01 -1.22E-01 -7.06E-01
Colon cancer 2B90 Colon tissue 1.44E-79 -1.02E+00 -2.59E+00
Coronary artery disease BA80-BA8Z Peripheral blood 5.65E-02 3.94E-01 9.26E-01
Diffuse large B-cell lymphoma 2A81 Tonsil tissue 6.98E-01 -7.52E-02 -3.34E-01
Endometriosis GA10 Endometrium tissue 2.21E-01 1.43E-01 4.95E-01
Familial hypercholesterolemia 5C80.00 Peripheral blood 3.70E-01 -3.62E-02 -1.78E-01
Familial hypercholesterolemia 5C80.00 Whole blood 2.13E-13 8.58E-01 2.51E+00
Gastric cancer 2B72 Gastric tissue 2.05E-01 -9.57E-01 -1.69E+00
Glioblastopma 2A00.00 Nervous tissue 9.53E-61 -4.64E-01 -1.08E+00
Glioma 2A00.0Y-2A00.0Z Brain stem tissue 4.43E-01 -6.03E-01 -7.75E-01
Glioma 2A00.0Y-2A00.0Z White matter tissue 6.26E-01 1.06E-01 2.32E-01
Head and neck cancer 2D42 Head and neck tissue 1.82E-19 -5.27E-01 -1.40E+00
HIV-associated neurocognitive impairment 8A2Y-8A2Z White matter tissue 2.07E-01 1.70E-01 3.10E-01
Huntington's disease 8A01.10 Whole blood 3.35E-01 1.99E-01 1.09E+00
Idiopathic pulmonary fibrosis CB03.4 Lung tissue 5.24E-02 -4.03E-01 -1.17E+00
Immunodeficiency 4A00-4A20 Peripheral blood 3.00E-02 -1.08E-01 -1.73E+00
Influenza 1E30 Whole blood 2.05E-02 -3.14E-01 -2.46E+00
Interstitial cystitis GC00.3 Bladder tissue 8.89E-01 -1.22E-02 -8.03E-02
Intracranial aneurysm 8B01.0 Intracranial artery 1.89E-02 -3.71E-01 -7.32E-01
Irritable bowel syndrome DD91.0 Rectal colon tissue 2.82E-02 -8.91E-02 -4.29E-01
Ischemic stroke 8B11 Peripheral blood 7.39E-01 4.11E-02 1.62E-01
Juvenile idiopathic arthritis FA24 Peripheral blood 3.36E-06 2.64E-01 6.94E-01
Lateral sclerosis 8B60.4 Skin 3.55E-01 -5.76E-02 -4.73E-01
Lateral sclerosis 8B60.4 Cervical spinal cord 5.40E-01 3.25E-01 8.61E-01
Liver cancer 2C12.0 Liver tissue 1.69E-02 -1.81E-01 -2.95E-01
Liver failure DB99.7-DB99.8 Liver tissue 1.01E-03 -1.45E+00 -1.66E+00
Lung cancer 2C25 Lung tissue 2.75E-38 -5.15E-01 -1.37E+00
Lupus erythematosus 4A40 Whole blood 7.45E-10 2.71E-01 7.17E-01
Major depressive disorder 6A70-6A7Z Hippocampus 3.72E-01 2.41E-02 1.86E-01
Major depressive disorder 6A70-6A7Z Whole blood 1.51E-02 1.48E-01 5.76E-01
Melanoma 2C30 Skin 5.45E-04 -1.67E+00 -1.26E+00
Multiple myeloma 2A83.1 Peripheral blood 2.98E-01 7.65E-02 3.58E-01
Multiple myeloma 2A83.1 Bone marrow 4.57E-02 8.76E-02 5.11E-01
Multiple sclerosis 8A40 Plasmacytoid dendritic cells 9.65E-01 5.13E-02 1.82E-01
Myelodysplastic syndrome 2A36-2A3Z Bone marrow 2.11E-06 2.95E-01 1.13E+00
Myelofibrosis 2A20.2 Whole blood 2.18E-01 5.24E-02 3.73E-01
Myocardial infarction BA41-BA50 Peripheral blood 3.35E-02 3.16E-01 5.87E-01
Myopathy 8C70.6 Muscle tissue 4.74E-02 -8.28E-02 -6.36E-01
Neonatal sepsis KA60 Whole blood 8.60E-26 6.30E-01 1.84E+00
Neuroectodermal tumour 2A00.11 Brain stem tissue 8.68E-06 -7.94E-01 -3.12E+00
Non-alcoholic fatty liver disease DB92 Liver tissue 6.11E-01 3.53E-01 5.69E-01
Obesity related type 2 diabetes 5A11 Omental adipose tissue 2.94E-02 4.30E-01 2.15E+00
Olive pollen allergy CA08.00 Peripheral blood 6.30E-01 -1.43E-04 -2.31E-04
Oral cancer 2B6E Oral tissue 5.40E-06 -6.36E-01 -1.21E+00
Osteoarthritis FA00-FA0Z Synovial tissue 1.35E-01 -1.38E-01 -2.22E-01
Osteoporosis FB83.1 Bone marrow 8.62E-01 0.00E+00 0.00E+00
Ovarian cancer 2C73 Ovarian tissue 3.90E-01 -1.96E-01 -5.23E-01
Pancreatic cancer 2C10 Pancreas 2.97E-01 1.48E-01 3.44E-01
Parkinson's disease 8A00.0 Substantia nigra tissue 3.18E-01 1.57E-02 4.86E-02
Pediatric respiratory syncytial virus infection CA40.11 Peripheral blood 1.35E-03 2.06E-01 7.27E-01
Pituitary cancer 2D12 Pituitary tissue 1.70E-01 7.64E-02 4.97E-01
Pituitary gonadotrope tumour 2D12 Pituitary tissue 1.85E-01 -1.66E-01 -6.79E-01
Polycystic ovary syndrome 5A80.1 Vastus lateralis muscle 2.91E-01 -8.80E-02 -6.51E-01
Polycythemia vera 2A20.4 Whole blood 4.67E-07 1.09E-01 7.32E-01
Pompe disease 5C51.3 Biceps muscle 3.91E-04 5.43E-01 2.38E+00
Preterm birth KA21.4Z Myometrium 7.15E-01 -4.37E-02 -1.42E-01
Prostate cancer 2C82 Prostate 2.68E-04 -1.11E-01 -3.55E-01
Psoriasis EA90 Skin 1.36E-07 -3.21E-01 -5.79E-01
Rectal cancer 2B92 Rectal colon tissue 1.57E-06 -6.09E-01 -4.04E+00
Renal cancer 2C90-2C91 Kidney 3.01E-03 -7.87E-01 -1.34E+00
Retinoblastoma 2D02.2 Uvea 2.01E-01 1.42E-01 3.43E-01
Rheumatoid arthritis FA20 Synovial tissue 7.89E-02 -7.53E-01 -9.23E-01
Rhinovirus infection CA42.1 Nasal epithelium tissue 2.54E-01 -4.15E-02 -2.23E-01
Schizophrenia 6A20 Prefrontal cortex 3.94E-02 3.47E-02 2.23E-01
Schizophrenia 6A20 Superior temporal cortex 2.35E-01 -8.02E-03 -3.68E-02
Scleroderma 4A42.Z Whole blood 2.62E-02 1.27E-01 6.17E-01
Seizure 8A60-8A6Z Whole blood 2.97E-01 -1.31E-01 -3.76E-01
Sensitive skin EK0Z Skin 8.81E-01 -2.13E-01 -7.94E-01
Sepsis with septic shock 1G41 Whole blood 9.29E-65 6.53E-01 2.05E+00
Shwachman-Diamond syndrome 3A70.0 Bone marrow 4.96E-02 -2.52E-01 -1.74E+00
Sickle cell disease 3A51.0-3A51.3 Peripheral blood 8.93E-01 -6.65E-02 -9.74E-02
Simpson golabi behmel syndrome LD2C Adipose tissue 9.55E-01 -1.81E-02 -1.18E-01
Sjogren's syndrome 4A43.2 Salivary gland tissue 3.60E-01 2.02E-01 7.77E-01
Skin cancer 2C30-2C3Z Skin 4.46E-21 -5.28E-01 -7.55E-01
Thrombocythemia 3B63 Whole blood 3.19E-03 6.78E-02 4.86E-01
Thrombocytopenia 3B64 Whole blood 5.41E-01 7.07E-01 1.12E+00
Thyroid cancer 2D10 Thyroid 5.98E-07 -1.79E-01 -8.78E-01
Tibial muscular dystrophy 8C75 Muscle tissue 2.11E-07 -5.99E-01 -3.14E+00
Tuberous sclerosis complex LD2D.2 Perituberal tissue 2.71E-01 1.11E-01 7.55E-01
Type 2 diabetes 5A11 Liver tissue 1.47E-01 3.09E-01 8.95E-01
Ureter cancer 2C92 Urothelium 8.00E-01 -1.96E-02 -1.11E-01
Uterine cancer 2C78 Endometrium tissue 4.81E-01 -9.40E-02 -2.49E-01
Vitiligo ED63.0 Skin 9.42E-01 -2.15E-01 -4.11E-01
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⏷ Show the Full List of DME Expression Under 107 Diseases

References

1 Sodium acetate induces a metabolic alkalosis but not the increase in fatty acid oxidation observed following bicarbonate ingestion in humans. J Nutr. 2007 Jul;137(7):1750-6.