Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEF01WC)

• DME Name: Beta-lactamase (blaB)
• Synonyms: Penicillinase; Cephalosporinase; Beta-lactam; NCTC9695_01822
• Gene Name: ampC
• UniProt ID: A0A3S4HKA9_CHRVL
• INTEDE ID: DME1643
• EC Number:
  EC: 3.5.2.6
  Hydrolases
  Carbon-nitrogen hydrolase
  Cyclic amide hydrolase
  EC: 3.5.2.6
• Lineage:
  Species: Chromobacterium violaceum
  Kingdom: Bacteria
  Phylum: Proteobacteria
  Class: Betaproteobacteria
  Order: Neisseriales
  Family: Chromobacteriaceae
  Genus: Chromobacterium
  Species: Chromobacterium violaceum
• Tissue Distribution: Primarily distributed in human skin.
• Sequence:
  MMQSLKFRTLAGMLGCLTFLPLAAQAANDAGKSDLDAAVEATIPPLMKAKDIPGMAVAVL
  ADGKAHYFNYGVASRETGQPVTQDTLFELGSISKTFTGILGGYALAQGKLSLADKASRYQ
  PELKGSVFDRVSLLQLATYSAGGLPLQFPDAVAGQASMLAYYRGWKPDYAPGERRLYSNP
  SIGLFGHLAARSLGQPFDQAMERGLLPKLGLSHTFIHVPEAEQSRYAWGYAKAGKPIRVG
  AGVLDAEAYGIKSSAADLLKYLAINMSPPADPALQRALDASHAAYYRVGDMRQGLGWEGY
  RYPISLERLLAGNSNEIAFQPQKVEWLNPPRLAEGDVLLNKTGSTSGFGAYVLFVPARKV
  GIVMLANRNYPNAERVRAAYRILLAVDPSLARRRGD
• Function: This enzyme hydrolyzes beta-lactam.

Molecular Interaction Atlas (MIA) of This DME

3 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbenicillin	DMLEDNK	Infection of the upper and lower urinary tract	GC08	Approved	[1]
Cefoxitin	DMY8NC4	Acute gonococcal cervicitis		Approved	[1]
Ticarcillin	DM4ME02	Aspiration pneumonia		Approved	[1]

References

• [1] Beta-lactamase activity in Chromobacterium violaceum. J Infect Dis. 1976 Sep;134(3):290-3.