Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEFKVZD)

• DME Name: Phospho-beta-glucosidase (LBA1706)
• Synonyms: Beta-glucosidase phospho; 6-phospho-beta-glucosidase; LBA1706
• Gene Name: LBA1706
• UniProt ID: Q5FIF6_LACAC
• INTEDE ID: DME1720
• Gene ID: 3251293
• EC Number:
  EC: 3.2.1.86
  Hydrolases
  Glycosylase
  O/S-glycosyl compound glycosidase
  EC: 3.2.1.86
• Lineage:
  Species: Lactobacillus acidophilus
  Kingdom: Bacteria
  Phylum: Firmicutes
  Class: Bacilli
  Order: Lactobacillales
  Family: Lactobacillaceae
  Genus: Lactobacillus
  Species: Lactobacillus acidophilus
• Tissue Distribution: Primarily distributed in human gut.
• Sequence:
  MNTYHVPHVFLWGVATSANQVEGAWNEEGKGISIADCERFNPNQDLDDYRKVNDMTTAEI
  ESAMQDKSSKSWGKRHGVDFYHYYQSDLELLAKMGINSMRTSIAWSRIFPNGDDARPNQK
  GLEFYDRLFTKMHELGIQPVVTLSHYEMPLNLVLNYDSWYDPKIIDYFYRFSKTVIDRYH
  DKVKYWLPINEIDSIIRHPYSSAGLVEDRFPNKNFKEVIYQSMHHQFVAAAKVTKYIHEN
  YLGHKVGSMITSTMVYPYNSDPRNMLKATQIMRESYNFSDVQLRGKYPQVLLKQMMEMGI
  HVKMSDKDLQLIKENTADFVAFSYYSSICTAHDTEGLQITKANRTIGVYNKYLPTSEWGW
  QIDPVGLRLIMINLYDRYQKPVFIVENGLGARDRLTYDFKIHDQYRIDYLRAHINEMLRS
  LTEDGIELMGYMIWGTTDMVSASTTQMSKRYGLIYVDLDDEGKGTCKRYLKDSYYWYQKL
  LSFKADIPVDYLN
• Function: This enzyme hydrolyzes several other phospho-beta-D-glucosides, but not their non-phosphorylated forms.
• KEGG Pathway:
  Glycolysis / Gluconeogenesis (lac00010)
  Starch and sucrose metabolism (lac00500)

Molecular Interaction Atlas (MIA) of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicin	DM1T2LS	Analgesia	MB40.8	Approved	[1]

References

• [1] Microbial unmasking of plant glycosides. mBio. 2018 Jan 30;9(1). pii: e02433-17.