Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEG1VAR)

DME Name	Beta-glucuronidase (uidA)
Synonyms	Beta-galactosidase/beta-glucuronidase; Beta-galactosidase BgaB; ACP_2665; GUS
Gene Name	uidA
UniProt ID	C1F2K5_ACIC5
INTEDE ID	DME1798
EC Number	EC: 3.2.1.31 Hydrolases Glycosylase O/S-glycosyl compound glycosidase EC: 3.2.1.31
Lineage	Species: Acidobacterium capsulatum Kingdom: Bacteria Phylum: Acidobacteria Class: Acidobacteriia Order: Acidobacteriales Family: Acidobacteriaceae Genus: Acidobacterium Species: Acidobacterium capsulatum Subspecies: Acidobacterium capsulatum NBRC 15755
Tissue Distribution	Primarily distributed in human gut.
Sequence	MAFARGGLAQTASQTTSSPVRVGLSVDASALGHTIPPDYTGLSYEQAQMANPNYFSGANT QLAGFLRTLGRQGVLRIGGNTSEYTFWNRHAKPTAADEHLAAGPDKGHHAAAREVITPEA VNNLSEFLDKTGWKLIYGLNLGKGTPENAADEAAYVMETIGADRLLAFQLGNEPDLFYRN GIRPASYDFAAYAGDWQRFFTAIRKRVPNAPFAGPDTAYNTKWLVPFADKFKHDVKFISS HYYAEGPPTDPSMTIERLMKPNPRLLGETAGLKQVEADTGLPFRLTETNSCYQGGKQGVS DTFAAALWAGDLMYQQAAAGSTGINFHGGGYGWYTPVAGTPEDGFIARPEYYGMLLFAQA GAGQLLGAKLTDNSAAPLLTAYALRGTDGRTRIALFNKNLDADVEVAISGVASPSGTVLR LEAPRADDTTDVTFGGAPVGASGSWSPLVQEYVPGHSGQFVLHMRKASGALLEFA
Function	This enzyme takes part in glucuronoside catabolic process. It catalyzes the hydrolysis of beta-glucuronide containing substrates.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PNB-D-xyloside	DMWPECH	N. A.	N. A.	Investigative	[1]
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References

1	Structural and biochemical characterization of glycoside hydrolase family 79 beta-glucuronidase from Acidobacterium capsulatum. J Biol Chem. 2012 Apr 20;287(17):14069-77.