Details of Drug-Metabolizing Enzyme (DME)
General Information of Drug-Metabolizing Enzyme (DME) (ID: DEG8NJD)
| DME Name | Alcohol dehydrogenase (ADH) | ||||
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| Synonyms | Alcohol dehydrogenase AdhP; Zinc-dependent alcohol dehydrogenase; Zn-dependent alcohol dehydrogenase; CYK00_08895 | ||||
| Gene Name | ADH | ||||
| UniProt ID | |||||
| INTEDE ID | |||||
| EC Number | EC: 1.1.1.1 | ||||
| Lineage | Species: Neisseria sicca | ||||
| Tissue Distribution | Primarily distributed in human oral cavity. | ||||
| Sequence |
MKAMVYHGANDIRFEEKPRPQIIDPTDAVVKIVKTTICGTDLGIWKGKNPEVADGRILGH
EGIGIVEEVGEAVKNIKVGDKVIISCVSKCCTCDNCKIQLYSHCRNGGWILGYIIDGTQA EYVRTPYADNSLVPLPDNVNEEVALLLSDALPTAHEIGVQYGDVKPGDTVFIAGAGPVGM SALLTAQLYSPAAIIVCDMDENRLKLAKELGATHTISPASGDVSKQVFAIVGEDGVDCAI EAVGIPATWNMCQDIVKPGGHIAVVGVHGQSVDFKLEKLWIKNLAITTGLVNANTTEMLM KAISSSSVDYTKMLTHHFKFSELEKAYDVFKHAAENQAMKVVLEAD |
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| Function | This enzyme acts on primary or secondary alcohols or hemi-acetals with very broad specificity and the enzyme oxidizes methanol much more poorly than ethanol. | ||||
Molecular Interaction Atlas (MIA) of This DME
| Molecular Interaction Atlas (MIA) | ||||||||||||||||||||||||||||
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1 Approved Drug(s) Metabolized by This DME
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