Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEGA738)

• DME Name: Beta-glucuronidase (uidA)
• Synonyms: Beta-galactosidase/beta-glucuronidase; Beta-galactosidase BgaB; GUS; JW1609; b1617; gurA; gusA; uidA
• Gene Name: uidA
• UniProt ID: BGLR_ECOLI
• INTEDE ID: DME1830
• Gene ID: 946149
• EC Number:
  EC: 3.2.1.31
  Hydrolases
  Glycosylase
  O/S-glycosyl compound glycosidase
  EC: 3.2.1.31
• Lineage:
  Species: Erysipelatoclostridium ramosum
  Kingdom: Bacteria
  Phylum: Firmicutes
  Class: Erysipelotrichia
  Order: Erysipelotrichales
  Family: Erysipelotrichaceae
  Genus: Erysipelatoclostridium
  Species: Erysipelatoclostridium ramosum
• Tissue Distribution: Primarily distributed in human gut.
• Sequence:
  MLRPVETPTREIKKLDGLWAFSLDRENCGIDQRWWESALQESRAIAVPGSFNDQFADADI
  RNYAGNVWYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVTP
  YVIAGKSVRITVCVNNELNWQTIPPGMVITDENGKKKQSYFHDFFNYAGIHRSVMLYTTP
  NTWVDDITVVTHVAQDCNHASVDWQVVANGDVSVELRDADQQVVATGQGTSGTLQVVNPH
  LWQPGEGYLYELCVTAKSQTECDIYPLRVGIRSVAVKGEQFLINHKPFYFTGFGRHEDAD
  LRGKGFDNVLMVHDHALMDWIGANSYRTSHYPYAEEMLDWADEHGIVVIDETAAVGFNLS
  LGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIARDKNHPSVVMWSIANEPDTRPQG
  AREYFAPLAEATRKLDPTRPITCVNVMFCDAHTDTISDLFDVLCLNRYYGWYVQSGDLET
  AEKVLEKELLAWQEKLHQPIIITEYGVDTLAGLHSMYTDMWSEEYQCAWLDMYHRVFDRV
  SAVVGEQVWNFADFATSQGILRVGGNKKGIFTRDRKPKSAAFLLQKRWTGMNFGEKPQQG
  GKQ
• Function: This enzyme takes part in glucuronoside catabolic process. It catalyzes the hydrolysis of beta-glucuronide containing substrates.
• KEGG Pathway:
  Biosynthesis of secondary metabolites (ecj01110)
  Metabolic pathways (ecj01100)
  Pentose and glucuronate interconversions (ecj00040)
  Porphyrin and chlorophyll metabolism (ecj00860)

Molecular Interaction Atlas (MIA) of This DME

1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin glucuronide	DMSBENK	N. A.	N. A.	Investigative	[2]

The Drug Therapeutic Target (DTT) Role of This DME

• DME DTT Name: Bacterial Beta-glucuronidase (Bact uidA) DTT Info
• DME DTT Type: Preclinical

1 Preclinical Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SBX-101	DMXN4UC	Intestinal toxicities from therapy	DA94.1	Preclinical	[1]

References

• [1] Microbiome therapeutics go small molecule. Nat Rev Drug Discov. 2019 Jul;18(8):569-572.
• [2] Developing a metagenomic view of xenobiotic metabolism. Pharmacol Res. 2013 Mar;69(1):21-31.