Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEH3KAT)

• DME Name: Methylenetetrahydrofolate reductase (metF)
• Synonyms: Methylene tetrahydrofolate reductase bacterial; AtMTHFR; Bacterial MTHFR; SSA_0417; metF
• Gene Name: metF
• UniProt ID: A3CL12_STRSV
• INTEDE ID: DME1957
• Gene ID: 4807150
• EC Number:
  EC: 1.5.1.20
  Oxidoreductase
  CH-NH donor oxidoreductase
  NAD/NADP acceptor oxidoreductase
  EC: 1.5.1.20
• Lineage:
  Species: Streptococcus sanguinis
  Kingdom: Bacteria
  Phylum: Firmicutes
  Class: Bacilli
  Order: Lactobacillales
  Family: Streptococcaceae
  Genus: Streptococcus
  Species: Streptococcus sanguinis
• Tissue Distribution: Primarily distributed in human oral cavity.
• Sequence:
  MVRRHTPSLSFEVFPPNPAVGNDKIFQALREMQDLAPHFISVTASNNKFDIEETTVRLTE
  FIANELQIPTIAHLPAVYLTKDMVSNILQSLDRVGVHQILALRGDIFPDVAPKDDFTYAT
  DLIEYIKTEAPHFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFY
  DFQDKCILAGIEVPIHAGIMPILNRNQALRLLKTCENIKLPRKFRAILDKYEHDPESLRA
  AGLAYAVDQIVDLVTQDVAGIHLYTMNNAATAYHIYKATHALFNHNPSVQSF
• Function: This enzyme is a flavoprotein (FAD). And Menadione can also serve as an electron acceptor.
• KEGG Pathway:
  Carbon metabolism (ssa01200)
  Metabolic pathways (ssa01100)
  Microbial metabolism in diverse environments (ssa01120)
  One carbon pool by folate (ssa00670)

Molecular Interaction Atlas (MIA) of This DME

1 Clinical Trial Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ISO-901	DMBQ8CA	N. A.	N. A.	Phase 1	[1]

References

• [1] Functional profiles of coronal and dentin caries in children. J Oral Microbiol. 2018 Jul 16;10(1):1495976.