Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEH49YS)

DME Name	Glutathione S-transferase alpha-2 (GSTA2)
Synonyms	Glutathione S-transferase A2; GST class-alpha member 2; GST-gamma; GST HA subunit 2; GST2; GSTA2; GSTA2-2; GTH2
Gene Name	GSTA2
UniProt ID	GSTA2_HUMAN
INTEDE ID	DME0081
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Gene ID	2939
EC Number	EC: 2.5.1.18 Transferase Alkyl/aryl transferase Alkyl/aryl transferase EC: 2.5.1.18
Lineage	Species: Homo sapiens Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens
Sequence	MAEKPKLHYSNIRGRMESIRWLLAAAGVEFEEKFIKSAEDLDKLRNDGYLMFQQVPMVEI DGMKLVQTRAILNYIASKYNLYGKDIKEKALIDMYIEGIADLGEMILLLPFSQPEEQDAK LALIQEKTKNRYFPAFEKVLKSHGQDYLVGNKLSRADIHLVELLYYVEELDSSLISSFPL LKALKTRISNLPTVKKFLQPGSPRKPPMDEKSLEESRKIFRF
Function	This enzyme conjugates reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
KEGG Pathway	Chemical carcinogenesis (hsa05204 ) Drug metabolism - cytochrome P450 (hsa00982 ) Drug metabolism - other enzymes (hsa00983 ) Fluid shear stress and atherosclerosis (hsa05418 ) Glutathione metabolism (hsa00480 ) Hepatocellular carcinoma (hsa05225 ) Metabolic pathways (hsa01100 ) Metabolism of xenobiotics by cytochrome P450 (hsa00980 ) Pathways in cancer (hsa05200 ) Platinum drug resistance (hsa01524 )
Reactome Pathway	Glutathione conjugation (R-HSA-156590 ) Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation (R-HSA-8950505 )

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This DME

2 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[1]
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[2]
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The Drug Therapeutic Target (DTT) Role of This DME

DME DTT Name	Glutathione S-transferase A2 (GSTA2) DTT Info
DME DTT Type	Literature-reported

References

1	PharmGKB: A worldwide resource for pharmacogenomic information. Wiley Interdiscip Rev Syst Biol Med. 2018 Jul;10(4):e1417. (ID: PA2040)
2	Endothelial cells do not express GSTA1: potential relevance to busulfan-mediated endothelial damage during haematopoietic stem cell transplantation. Eur J Haematol. 2008 Apr;80(4):299-302.