Details of Drug-Metabolizing Enzyme (DME)
General Information of Drug-Metabolizing Enzyme (DME) (ID: DEH4O6C)
| DME Name | Thymidylate synthase (thyA) | ||||
|---|---|---|---|---|---|
| Synonyms | Bacterial dihydrofolate reductase-thymidylate synthase; dTMP synthase; BgDHFR-TS; DHFR-TS; HTS; thyA | ||||
| Gene Name | thyA | ||||
| UniProt ID | |||||
| INTEDE ID | |||||
| 3D Structure | |||||
| EC Number | EC: 2.1.1.45 | ||||
| Lineage | Species: Lactobacillus casei | ||||
| Tissue Distribution | Primarily distributed in human gut. | ||||
| Sequence |
MLEQPYLDLAKKVLDEGHFKPDRTHTGTYSIFGHQMRFDLSKGFPLLTTKKVPFGLIKSE
LLWFLHGDTNIRFLLQHRNHIWDEWAFEKWVKSDEYHGPDMTDFGHRSQKDPEFAAVYHE EMAKFDDRVLHDDAFAAKYGDLGLVYGSQWRAWHTSKGDTIDQLGDVIEQIKTHPYSRRL IVSAWNPEDVPTMALPPCHTLYQFYVNDGKLSLQLYQRSADIFLGVPFNIASYALLTHLV AHECGLEVGEFIHTFGDAHLYVNHLDQIKEQLSRTPRPAPTLQLNPDKHDIFDFDMKDIK LLNYDPYPAIKAPVAV |
||||
| Function |
This enzyme catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.
|
||||
Molecular Interaction Atlas (MIA) of This DME
| Molecular Interaction Atlas (MIA) | ||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
1 Investigative Drug(s) Metabolized by This DME
|
||||||||||||||||||||||||||||