Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEIF4P9)

DME Name VanC2 ligase (vanC)
Synonyms Vancomycin C-type resistance protein VanC; VanC ligase; vanC
Gene Name vanC
UniProt ID
VANC_ENTGA
INTEDE ID
DME1185
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number EC: 6.3.2.4
Ligase
Carbon-nitrogen ligase
Peptide synthase
EC: 6.3.2.4
Lineage Species: Enterococcus gallinarum
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Enterococcaceae
Genus: Enterococcus
Species: Enterococcus gallinarum

Subspecies: Enterococcus gallinarum BM4174
Tissue Distribution Primarily distributed in human gut.
Sequence
MKKIAVLFGGNSPEYSVSLTSAASVIQAIDPLKYEVMTIGIAPTMDWYWYQGNLANVRND
TWLEDHKNCHQLTFSSQGFILGEKRIVPDVLFPVLHGKYGEDGCIQGLLELMNLPYVGCH
VAASALCMNKWLLHQLADTMGIASAPTLLLSRYENDPATIDRFIQDHGFPIFIKPNEAGS
SKGITKVTDKTALQSALTTAFAYGSTVLIQKAIAGIEIGCGILGNEQLTIGACDAISLVD
GFFDFEEKYQLISATITVPAPLPLALESQIKEQAQLLYRNLGLTGLARIDFFVTNQGAIY
LNEINTMPGFTGHSRYPAMMAEVGLSYEILVEQLIALAEEDKR
Function
This enzyme is required for low-level resistance to the glycopeptide antibiotic vancomycin and it may synthesize a dipeptide or a depsipeptide which is incorporated into peptidoglycan precursors and not recognized by vancomycin.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DME
1 Approved Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
Vancomycin DM3JFIH Bacteremia 1A73 Approved [1]

References

1 Sequence of the vanC gene of Enterococcus gallinarum BM4174 encoding a D-alanine:D-alanine ligase-related protein necessary for vancomycin resistance. Gene. 1992 Mar 1;112(1):53-8.