General Information of Drug-Metabolizing Enzyme (DME) (ID: DEIN8FB)

DME Name Glycerol/diol dehydratase (dhaB)
Synonyms Glycerol dehydratase; Propanediol dehydratase pduC; dhaB; gldC; pduC
Gene Name gldC
UniProt ID
H6V877_LACRE
INTEDE ID
DME1923
EC Number EC: 4.2.1.30
Lyases
Carbon-oxygen lyase
Hydro-lyase
EC: 4.2.1.30
Lineage Species: Lactobacillus reuteri
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
Species: Lactobacillus reuteri
Tissue Distribution Primarily distributed in human gut.
Sequence
RYAPFNAISILIGAQTGRPGVLTQCSVEEATELQLGMRGFTAYAETISVYGTDRVFTDGD
DTPWSKGFLASCYASRGLKMRFTSGAGSEVLMGYPEGKSMLYLEARCILLTKASGVQGLQ
NGAVSCIEIPGAVPNGIREVLGENLLCMMCDIEC
Function This enzyme has two forms. One form requires a cobamide coenzyme, while the other is a glycyl radical enzyme.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DME
1 Investigative Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE DMNQL17 Discovery agent N.A. Investigative [1]

References

1 Gut microbial beta-glucuronidase and glycerol/diol dehydratase activity contribute to dietary heterocyclic amine biotransformation. BMC Microbiol. 2019 May 16;19(1):99.