Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEKW6PB)

• DME Name: Gamma-glutamylcyclotransferase (GGCT)
• Synonyms: Gamma-glutamyl cyclotransferase; Glutamylcyclo-transferase gamma; Cytochrome c-releasing factor 21; AR466_12245
• Gene Name: GGCT
• UniProt ID: A0A073ACX1_RALSL
• INTEDE ID: DME1353
• EC Number:
  EC: 4.3.2.9
  Lyases
  Carbon-nitrogen lyase
  Amidine-lyase
  EC: 4.3.2.9
• Lineage:
  Species: Ralstonia solanacearum
  Kingdom: Bacteria
  Phylum: Proteobacteria
  Class: Betaproteobacteria
  Order: Burkholderiales
  Family: Burkholderiaceae
  Genus: Ralstonia
  Species: Ralstonia solanacearum
• Tissue Distribution: Primarily distributed in human vagina.
• Sequence:
  MAVTREDLEQNRLRAALGDSPVASTLLTEAALEASLTSTLARLSAPPCDGQDAWVFGYGS
  LIWNPMIFHTEATCATVHGYHRGFYLYSRINRGTWDNPGLVLGLDRGGSCHGVAFRVPRA
  HAEREFRVLWRREMMTGAYLPRWLPTEIHGERILALAFVMNRTHEAYAGRLPDERVLGCL
  HKAVGLYGPAREYLQRTLIGLASNGLHDPYLDRLWQRLQAMDAANAPSQAEDATGTGPSP
  DPYLSA
• Function: This enzyme acts on derivatives of L-glutamate, L-2-aminobutanoate, L-alanine and glycine and acts as a cyclotransferase, cleaving the amide bond via transamidation using the alpha-amine of the L-glutamyl residue, releasing it as the cyclic 5-oxo-L-proline.
• KEGG Pathway:
  Glutathione metabolism (rsy00480)
  Metabolic pathways (rsy01100)

Molecular Interaction Atlas (MIA) of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[1], [2]

References

• [1] Characterization of the mechanism of thioredoxin-dependent activation of gamma-glutamylcyclotransferase, RipAY, from Ralstonia solanacearum. Biochem Biophys Res Commun. 2020 Mar 12;523(3):759-765.
• [2] Vaginal microbiome in early pregnancy and subsequent risk of spontaneous preterm birth: a case-control study. BJOG. 2019 Feb;126(3):349-358.