Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEKW6PB)

DME Name	Gamma-glutamylcyclotransferase (GGCT)
Synonyms	Gamma-glutamyl cyclotransferase; Glutamylcyclo-transferase gamma; Cytochrome c-releasing factor 21; AR466_12245
Gene Name	GGCT
UniProt ID	A0A073ACX1_RALSL
INTEDE ID	DME1353
EC Number	EC: 4.3.2.9 Lyases Carbon-nitrogen lyase Amidine-lyase EC: 4.3.2.9
Lineage	Species: Ralstonia solanacearum Kingdom: Bacteria Phylum: Proteobacteria Class: Betaproteobacteria Order: Burkholderiales Family: Burkholderiaceae Genus: Ralstonia Species: Ralstonia solanacearum
Tissue Distribution	Primarily distributed in human vagina.
Sequence	MAVTREDLEQNRLRAALGDSPVASTLLTEAALEASLTSTLARLSAPPCDGQDAWVFGYGS LIWNPMIFHTEATCATVHGYHRGFYLYSRINRGTWDNPGLVLGLDRGGSCHGVAFRVPRA HAEREFRVLWRREMMTGAYLPRWLPTEIHGERILALAFVMNRTHEAYAGRLPDERVLGCL HKAVGLYGPAREYLQRTLIGLASNGLHDPYLDRLWQRLQAMDAANAPSQAEDATGTGPSP DPYLSA
Function	This enzyme acts on derivatives of L-glutamate, L-2-aminobutanoate, L-alanine and glycine and acts as a cyclotransferase, cleaving the amide bond via transamidation using the alpha-amine of the L-glutamyl residue, releasing it as the cyclic 5-oxo-L-proline.
KEGG Pathway	( ) ( )

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[1], [2]
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References

1	Characterization of the mechanism of thioredoxin-dependent activation of gamma-glutamylcyclotransferase, RipAY, from Ralstonia solanacearum. Biochem Biophys Res Commun. 2020 Mar 12;523(3):759-765.
2	Vaginal microbiome in early pregnancy and subsequent risk of spontaneous preterm birth: a case-control study. BJOG. 2019 Feb;126(3):349-358.