Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEL0D64)

• DME Name: Dopamine dehydroxylase (dadH)
• Synonyms: Inactive dopamine dehydroxylase; Dopamine de-monooxygenase; dadH; DADH; C1859_04790
• Gene Name: dadH
• UniProt ID: DADH_EGGLN
• INTEDE ID: DME1037
• EC Number:
  EC: 1.1.1.-
  Oxidoreductase
  CH-OH donor oxidoreductase
  NAD/NADP oxidoreductase
  EC: 1.1.1.-
• Lineage:
  Species: Eggerthella lenta
  Kingdom: Bacteria
  Phylum: Actinobacteria
  Class: Coriobacteriia
  Order: Eggerthellales
  Family: Eggerthellaceae
  Genus: Eggerthella
  Species: Eggerthella lenta
• Tissue Distribution: Primarily distributed in human gut.
• Sequence:
  MGNLTMSRRTFVKTAAITGAAAAAFGASTHTALAEETYSSVSGNDTVAVKTCCRGCGKME
  CGVKVIVQNGRAIRVEGDEGAFQSMGNCCTKSQSSIQAAYHPDRLHYPMKRTNPKGEEPG
  WQRISWDEAMQSIVDNFMDIKAKHGGEAIACQVGTSRIWCMHSESILKNMLETPNNVEAW
  QICKGPRHFATTMVSQFAMSWMETITRPKVYVQWGGASELSNYDDSCRTTVDVASRADVH
  ISVDPRMANMGKEADYWQHLRPGTDGALALAWTNVIIEKKLYDELYVKKWTNAPFLVCED
  MEPSGFPTVRTDGSYWDVKTALLKESDIKEGGSPYKFLVYDNNWEKLKAEGVEHEYGAFT
  WFNADQEGVIDETGGFWEGENYDSEKARQGREAAQDNLLPGQTQGWLPDPMPFDPAIDPA
  LEGEFEITLKDGKTVKVKPVWEHYKARAAEYKPEVAAEITGIPASEIEAAATAYGTRIDP
  STGYGNGGIQYMLAVEHFCSAIQNCRAFDNLVGITGNMDTPGGNRGPTIVPIDGDLQGFS
  AWAPGATTPPEEVNRKQIGIDKFPLLGWWQYWCDSHSLWDAVITGDPYPVRALWNESGNF
  MSQTNTTRAWEALCSLDFYVDLNLWHTPQNDTADIILPVAHWIELNSPRASQGSAGAMGA
  TVKCVQPPAEAKYDPEIVMDLARRMNWKWTDEPGNEWPDINWQLDDSIKLLTDDELTYTT
  WHVENGKPTFERHGVPMAEVTPKYKTWDEYVKAFQEHGWWQAKDIEPRNWGTYRRYQTGA
  MRARDRVWGRLDYTAGKGIGDWKPGWFTPTMKQEIWSTVMESHHPDHPEWRLPTYTEPPH
  GPKDGDRIKEYPLTATTGRRIPVYFHSEHRQLPWCRELWPVPRVEINPKTAAEYGIEQGD
  WVWIETEWGKIREVADLYYGVKEDVINLEHTWWYPEVKDAGHGWQFSQVNQLIDHYAQDP
  HSGTSNLRAYQVKIYKATPENSPFNNPVPCDSTGTPIIHTSDDPRLKEWLPTYEGRE
• Function: This enzyme involves in drug metabolism, as part of an interspecies gut bacterial pathway for Levodopa (L-dopa) metabolism, acting on dopamine produced by Enterecoccus L-dopa decarboxylase. Removes the para hydroxyl group of dopamine to produce m-tyramine (3-tyramine).

Molecular Interaction Atlas (MIA) of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dopamine	DMPGUCF	Parkinson disease	8A00.0	Approved	[1]

References

• [1] Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism. Science. 2019 Jun 14;364(6445). pii: eaau6323.