General Information of Drug-Metabolizing Enzyme (DME) (ID: DELQJ5O)

DME Name Beta-glucuronidase (uidA)
Synonyms Beta-galactosidase/beta-glucuronidase; Beta-galactosidase BgaB; ERS852554_01806; uidA_2
Gene Name uidA_2
UniProt ID
A0A174R8A7_BACUN
INTEDE ID
DME1194
EC Number EC: 3.2.1.31
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.31
Lineage Species: Bacteroides thetaiotaomicron
Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Bacteroidaceae
Genus: Bacteroides
Species: Bacteroides thetaiotaomicron

Subspecies: Bacteroides thetaiotaomicron str. 3978 T3 i
Tissue Distribution Primarily distributed in human gut.
Sequence
MITCLLTVSVLGGKSQAQDLLSNVYGRDYRLLNGKWGAIVDLYDQGERMQVYKNRKPQDN
KQFYEYSFDGGLVLNVPADFNSQMPELKFYEGTVWYGRSFDTPKTDGKRLFLYFGAVSYR
SKIYLNGEKIASHEGGFTPFQVEITDKVKQKDNFLVVKVNNTRTTDAIPAMSFDWWNYGG
ITRDVMLVSVPQSYIKDHFIQLDKVQSNLIRAKVTLSEAKPGINVQVAIPELGIRQNMTT
DANGIARATIKTKKLQRWSPDAPKLYDVTITSESDRLNEQIGFRNLYVKGEDIYLNDRPI
FLRSVSFHEEIPQRRGRAFSEADATMLLSEAKELGANMIRLAHYPQNEYTVRLAERMGFL
LWEEIPIWQGIDFKNTATREKAGRMIKEMVMRDKNRCSVAFWGIANETATSTPRNEFLKH
MKQCCLDIDSTRLITAAFDLVRFNRESRNFEMNDSIINILDMVAINKYMGWYHDWPLAPD
QAVWNVAPGKPLFISEFGGEALYGKHGDAEVKSSWSEDYQAQLYKDNLEMFKHIPNLRGT
SPWILFDFRSPFRFHPHQGGEWNRKGLVSDQGQRKKAWYIMRDYYNQKKTEQ
Function This enzyme takes part in glucuronoside catabolic process. It catalyzes the hydrolysis of beta-glucuronide containing substrates.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DME
2 Investigative Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
MUG trihydrate DM16F75 N. A. N. A. Investigative [1]
SN-38G DM2UVNB N. A. N. A. Investigative [1]

References

1 Three structurally and functionally distinct beta-glucuronidases from the human gut microbe Bacteroides uniformis. J Biol Chem. 2018 Nov 30;293(48):18559-18573.