Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DELUCK5)

• DME Name: Oligosaccharyltransferase (pglB)
• Synonyms: Oligosaccharyl transferase pglB; Oligo-saccharyl transferase; pglB; HCAN_0729
• Gene Name: pglB
• UniProt ID: C5ZWC5_9HELI
• INTEDE ID: DME1500
• EC Number:
  EC: 2.4.99.19
  Transferase
  Glycosyltransferases
  Glycosyltransferase
  EC: 2.4.99.19
• Lineage:
  Species: Helicobacter canadensis
  Kingdom: Bacteria
  Phylum: Proteobacteria
  Class: Epsilonproteobacteria
  Order: Campylobacterales
  Family: Helicobacteraceae
  Genus: Helicobacter
  Species: Helicobacter canadensis
• Tissue Distribution: Primarily distributed in human gut.
• Sequence:
  MEFQKHWLLMIQISVLFLSQKVCLHEIQELLNAKNMEKEKQEEVLNFQKDNQLPSFGLDF
  ISFSFRNLKNQLFIRLTSHSFFWHFVLLFIIFLLPLLFHYFDYLAFLKDSQNFFENTLIL
  TSYDSYFYAKGAKEFLETFNFNLPYLSVLGGILAKIFGLDNVLVWSSVFLSASFGVVLYF
  VIFEVLEYLAILTQKANQIFAFLGAFFGVLSPHFYQRNGVGYFDTDMLILSLPLLAIFCL
  WQYLIKRQFYFLFFFSIVAFLSVGWHSGIQNLLLAGFLLYVGYEIFNILVFKHTKSPILL
  ISSLFLIILTPSSYGFFVLLLALVVFYFEKSKISWVVFCIACVYAYFFGLFNPMIAQLKA
  YLFGEIQYSKTFIYASVVESILETSKANFTTLMQRSGGVGLFFLGLIGFVGFGFYYSLVR
  KNFIYLCIFLFPFLLLGFAALKLGVRFSFFLSPILALGCVLLVVGFLEIIRRFLKITLLI
  FAGILAIWVANLEYIIPKPILKAQEIEGLRALSFNSQDVAFVWWDYGYALEYFTQAQTLL
  HGGRHSGIVNYPIAEILLSHSAILAKNLSLLLAQKMQEIPKSQWNQIFEIVLKESNQTPQ
  NFLRQLTLDRFRLSDYPKGEVYWILPKKMLYLIANINGFRNVDLESGERIKEGIFLYEKT
  SLKTKEEDIFFKDFYLKKIQNGALAAKLIFEDRQFVMDFDYLQSNLIQWLVFKNNPVMNL
  VFENESVLIYQIPKE
• Function: This enzyme requires Mn2+ or Mg2+ and forms a glycoprotein by the transfer of a glucosyl-N-acetylgalactosaminyl-N,N'-diacetylbacillosamine (GalNAc2(Glc)GalNAc3diNAcBac) polysaccharide and related oligosaccharides to the side-chain of an L-asparagine residue in the sequence -Asp/Glu-Xaa-Asn-Xaa'-Ser/Thr- (Xaa and Xaa' not Pro) in nascent polypeptide chains.

Molecular Interaction Atlas (MIA) of This DME

1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
4'-GALACTOSYLLACTOSE	DMRF9NH	Hyperlipidaemia	5C80	Investigative	[1]

References

• [1] Characterization of N-linked protein glycosylation in Helicobacter pullorum. J Bacteriol. 2010 Oct;192(19):5228-36.