Details of Drug-Metabolizing Enzyme (DME)
General Information of Drug-Metabolizing Enzyme (DME) (ID: DEN6VO0)
| DME Name | VanA ligase (vanA) | ||||
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| Synonyms | Vancomycin/teicoplanin A-type resistance protein VanA; D-alanylalanine synthetase VanA; D-alanine--D-alanine ligase VanA; D-Ala-D-Ala ligase VanA; NCTC12360_01403; vanA | ||||
| Gene Name | vanA | ||||
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| INTEDE ID | |||||
| EC Number | EC: 6.3.2.4 | ||||
| Lineage | Species: Enterococcus gallinarum | ||||
| Tissue Distribution | Primarily distributed in human gut. | ||||
| Sequence |
MMKKIAVLFGGNSPEYSVSLASAASVIQAIDPLKYEVMTIGIAPTMDWYLYQGNLKNVRN
DTWLEDHKNCHQLTFSSQGFMLGEKRIVPDVLFPVLHGKYGEDGCIQGLLELMNLPYVGC HVAASALCMNKWLLHQLADTMGIASAPTLLLSRYENDPATIDRFIQDHGFPIFIKPNEAG SSKGITKVTDKTALQSALTNAFAYGSTVLIQKAIAGIEIGCGILGNEQLTIGACDAISLV DGFFDFEEKYQLISATITVPAPLPLALESQIKEQAQLLYRNLGLTGLARIDFFVTDQGAI YLNEINTMPGFTGHSRYPAMMAEVGLSYEMLVEQLIALAEEDKR |
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| Function |
This enzyme is involved with UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---L-lysine ligase (EC 6.3.2.7) or UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---2,6-diaminopimelate ligase (EC 6.3.2.13), UDP-N-acetylmuramate---L-alanine ligase (EC 6.3.2.8), UDP-N-acetylmuramoyl-L-alanine---D-glutamate ligase (EC 6.3.2.9) and UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase (EC 6.3.2.10) in the synthesis of a cell-wall peptide.
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Molecular Interaction Atlas (MIA) of This DME
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2 Approved Drug(s) Metabolized by This DME
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