Details of Drug-Metabolizing Enzyme (DME)
General Information of Drug-Metabolizing Enzyme (DME) (ID: DEO97D6)
| DME Name | VanA ligase (vanA) | ||||
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| Synonyms | Vancomycin/teicoplanin A-type resistance protein VanA; D-alanylalanine synthetase VanA; D-alanine--D-alanine ligase VanA; D-Ala-D-Ala ligase VanA; vanA | ||||
| Gene Name | vanA | ||||
| UniProt ID | |||||
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| 3D Structure | |||||
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| EC Number | EC: 6.3.2.4 | ||||
| Lineage | Species: Enterococcus faecium | ||||
| Tissue Distribution | Primarily distributed in human gut. | ||||
| Sequence |
MNRIKVAILFGGCSEEHDVSVKSAIEIAANINKEKYEPLYIGITKSGVWKMCEKPCAEWE
NDNCYSAVLSPDKKMHGLLVKKNHEYEINHVDVAFSALHGKSGEDGSIQGLFELSGIPFV GCDIQSSAICMDKSLTYIVAKNAGIATPAFWVINKDDRPVAATFTYPVFVKPARSGSSFG VKKVNSADELDYAIESARQYDSKILIEQAVSGCEVGCAVLGNSAALVVGEVDQIRLQYGI FRIHQEVEPEKGSENAVITVPADLSAEERGRIQETAKKIYKALGCRGLARVDMFLQDNGR IVLNEVNTLPGFTSYSRYPRMMAAAGIALPELIDRLIVLALKG |
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| Function |
This enzyme is required for high-level resistance to glycopeptide antibiotics. D-Ala--D-Ala ligase of altered specificity catalyzes ester bond formation between D-Ala and various D-hydroxy acids and produces a peptidoglycan which does not terminate in D-alanine but in D-lactate, thus preventing vancomycin or teicoplanin binding.
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Molecular Interaction Atlas (MIA) of This DME
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2 Approved Drug(s) Metabolized by This DME
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