Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEPDE7J)

• DME Name: Glycosyl hydrolase (glyH)
• Synonyms: Glycosidase; Glycoside hydrolase; Furcatin hydrolase; Isoflavonoid 7-O-apiosylglucosidase; BRYFOR_06869; bglB
• Gene Name: glyH
• UniProt ID: C6LE20_9FIRM
• INTEDE ID: DME1726
• EC Number:
  EC: 3.2.1.18
  Hydrolases
  Glycosylase
  O/S-glycosyl compound glycosidase
  EC: 3.2.1.18
• Lineage:
  Species: Marvinbryantia formatexigens
  Kingdom: Bacteria
  Phylum: Firmicutes
  Class: Clostridia
  Order: Clostridiales
  Family: Lachnospiraceae
  Genus: Marvinbryantia
  Species: Marvinbryantia formatexigens
• Tissue Distribution: Primarily distributed in human gut.
• Sequence:
  MKFTEGYWLRSERANGLFAAEAYAVEKIPGGMRVVAPVTRIGSRGDTLNMPVITIEFRAC
  AKGTISVKAWHYEGYDSHLPQFEKKEDIYDADVQISEEEAVLDTGLLKVRVSRKNFGYSF
  EADGKVLTSCGFRNLGYMRWDRQVSTMYPADNYLTEAHKPYMVNELSLSVGERVYGFGER
  FTAFVKNGQTVDIWNEDGGTASQLAYKNIPFYMTNRGYGVFVDCSDHVSFEVASEKVEYV
  GFSVPGESLSYYFFYGPQPKQILNAYTALTGRPALPPAWSFGLWLSTSFTTNYDEETTSF
  MIDGMAQRGIPLRVFHFDCFWMKAFHWCDFEWDKDCFPDIRGTLARYHEKGLKICVWINP
  YIAQGTPFFKEGAQNGYLLKRADGKGVWQTDNWQAGMGLVDFTNPDAVRWYTGKLKTLLD
  CGVDCFKTDFGERIPVNVSYYDGSDPHAMHNYYTFLYNRTVFNLLKEVKGEQEAVLFARS
  ATAGCQQFPVHWGGDCFANYPSMAETLRGGLSFAMSGFSFWSHDISGFESTATPDLYKRW
  AAFGLLSTHSRLHGSSSYRVPWNFDEEACDVVAFFTKLKCRLMPYLYAKAVEAHREGTPV
  MRPMVFEFMEDTAVAYIDTQYMLGEALLVAPIFREDSVCEYYLPEGTWTHLLDGGVKEGG
  IWRKETYDYFSLPLYVRENTLLALGADETRPDYAYEEGMSLRLYQLQDGQTAVCRVPDTA
  GEIVNVITARRKNAEITLCLEKAAGDIPLTIYDGECTKETVIPAGTGELQVSLED
• Function: This enzyme does not act on 4-O-acetylated sialic acids and it has no alpha-N-acetylgalactosaminidase activity.

Molecular Interaction Atlas (MIA) of This DME

1 Clinical Trial Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
LS-69767	DM8VBQJ	N. A.	N. A.	Phase 1	[1]

References

• [1] In vitro fermentation of fructooligosaccharides with human gut bacteria. Food Funct. 2015 Mar;6(3):947-54.