Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEPGFHV)

• DME Name: Beta-lactamase (blaB)
• Synonyms: Penicillinase; Cephalosporinase; Beta-lactam; mrdA; DBX42_08650
• Gene Name: mrdA
• UniProt ID: A0A316SS50_9PROT
• INTEDE ID: DME2070
• EC Number:
  EC: 3.5.2.6
  Hydrolases
  Carbon-nitrogen hydrolase
  Cyclic amide hydrolase
  EC: 3.5.2.6
• Lineage:
  Species: Azospirillum brasilense
  Kingdom: Bacteria
  Phylum: Proteobacteria
  Class: Alphaproteobacteria
  Order: Rhodospirillales
  Family: Rhodospirillaceae
  Genus: Azospirillum
  Species: Azospirillum brasilense
• Tissue Distribution: Primarily distributed in human skin.
• Sequence:
  MNRDNDKGKVLIRRSLIMALGKFFLLLVIVGRLYYLQVYQADRYKTLADENRISTRLLIP
  PRGVIYDRNGVMIATNTQNFQALIVAEQTPNVQETLDAFKKIMPLSADEEEKIKRDMKRN
  RSFVPIKIKENLTWEEVSRIQLNAADLPGIYIDEGLSRDYPFGPSMAHILGYVAAVNEKE
  AKQDDDPLLQVPGFKIGKSGIEKRYEKELRGKGGSLKLEVNAYGRIMKEIEKNDGIPGQP
  LTLTIDSRLQQKAFELFGEESGAAVLLDVNTGEILAFVSAPSFDPNLMTKGVSNTDWKAW
  LNNEKRPLTDKAISGQYSPGSTFKVLVALAALESGVIKPDTHFYCSGQMTLGNHIFHDWK
  RGGHGSLNVVEALAHSCDIFFYEVALRLGIEKIADMARRFGLGSRIDVGLENEKAGLIPD
  KEWKLRRFGEPWQQGESVISGIGQGYILTTPLQLATMVARIANGGYEVKPTFTKVKDKST
  IRKIDVADENIKLVKDGMFAVVNIPGSTAYRSHFDYNGQMMSGKTGSTQVRRITMKERQT
  RVLKQNELPWKYRDHGLFIAYAPHDNPRYAVAVLVEHGGGGSSAAAPIASKLLLETLKLD
  PVNEKVRTVE
• Function: This enzyme hydrolyzes beta-lactam.

Molecular Interaction Atlas (MIA) of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ceftiofur	DMR2SOZ	Bacterial infection	1A00-1C4Z	Approved	[1], [2]

References

• [1] Isolation of bacterial strains from bovine fecal microflora capable of degradation of ceftiofur. Vet Microbiol. 2009 Oct 20;139(1-2):89-96.
• [2] Granulomatous infection of the hand and wrist due to Azospirillum spp. Diagn Microbiol Infect Dis. 2013 Aug;76(4):513-5.