General Information of Drug-Metabolizing Enzyme (DME) (ID: DEPH3S7)

DME Name VanG ligase (vanG)
Synonyms Vancomycin G-type resistance protein VanG; D-alanylalanine synthetase VanG; D-alanine--D-alanine ligase VanG; D-Ala-D-Ala ligase VanG; vanG
Gene Name vanG
UniProt ID
A0A076ZC24_STRAP
INTEDE ID
DME1186
EC Number EC: 6.3.2.4
Ligase
Carbon-nitrogen ligase
Peptide synthase
EC: 6.3.2.4
Lineage Species: Streptococcus anginosus
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Streptococcaceae
Genus: Streptococcus
Species: Streptococcus anginosus
Tissue Distribution Primarily distributed in human gut.
Sequence
MQNKKIAVIFGGNSTEYEVSLQSASAVFENINTNKFDIIPIGITRSGEWYHYTGEKEKIL
NNTWFEDSKNLCPVVVSQNRSVKGFLEIASDKYRIIKVDLVFPVLHGKNGEDGTLQGIFE
LAGIPVVGCDTLSSALCMDKDRAHKLVSLAGISVPKSVTFKRFNEEAAMKEIEANLTYPL
FIKPVRAGSSFGITKVIEKQELDAAIELAFEHDTEVIVEETINGFEVGCAVLGIDELIVG
RVDEIELSSGFFDYTEKYTLKSSKIYMPARIDAEAEKRIQEAAVTIYKALGCSGFSRVDM
FYTPSGEIVFNEVNTIPGFTSHSRYPNMMKGIGLSFSQMLDKLIGLYVE
Function
This enzyme is involved with UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---L-lysine ligase (EC 6.3.2.7) or UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---2,6-diaminopimelate ligase (EC 6.3.2.13), UDP-N-acetylmuramate---L-alanine ligase (EC 6.3.2.8), UDP-N-acetylmuramoyl-L-alanine---D-glutamate ligase (EC 6.3.2.9) and UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase (EC 6.3.2.10) in the synthesis of a cell-wall peptide.
KEGG Pathway
Two-component system (sans02020 )
Vancomycin resistance (sans01502 )

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DME
1 Approved Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
Vancomycin DM3JFIH Bacteremia 1A73 Approved [1]

References

1 vanG element insertions within a conserved chromosomal site conferring vancomycin resistance to Streptococcus agalactiae and Streptococcus anginosus. mBio. 2014 Jul 22;5(4):e01386-14.