Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEPYGS9)

DME Name	Beta-lactamase (blaB)
Synonyms	Penicillinase; Cephalosporinase; Beta-lactam; BBRI4_5c12
Gene Name	blaB
UniProt ID	A0A0L0LVQ7_BIFBR
INTEDE ID	DME1349
EC Number	EC: 3.5.2.6 Hydrolases Carbon-nitrogen hydrolase Cyclic amide hydrolase EC: 3.5.2.6
Lineage	Species: Bifidobacterium breve Kingdom: Bacteria Phylum: Actinobacteria Class: Actinobacteria Order: Bifidobacteriales Family: Bifidobacteriaceae Genus: Bifidobacterium Species: Bifidobacterium breve
Tissue Distribution	Primarily distributed in human gut.
Sequence	MPRSVSSSSYPHEYSRHASHAAKPHRPHPQPCKPRQLRLDWQALLRFFQNLSERLPQRHH GKVKILKGSVYTRRRIVVGCLGVLLLVELFQLFWPSDKFFPLATLDGHAVGGQSSQQAAE TLNAATLKRTVKLTDKTTGTTVSLTAKQAGITVDYTDRAKAAAKHSVVKRIVPFSWLFVH STTSDSLPDALGTSDKQAHEDMRNASVQGTKGELKIVSAAPGYTFTSADIRSAAGSSFSS SATGDLAAATIEMGIVSPTVSDDTAEQLLDTLNKALSKDVTFTYEDGTWTVPAKKIINTV STTVNAQDNTKLDVTISESKLMRQLKSKGIALKVAKKAADAGVTPATIAVKGSAYQVIDA SATAASLSGMLASGQNAPVAVSTKDFSNVELYEGLPASGTIEEKLQQLFGDADYEVAVYD LKTGKSKIQIDADTAMTSASTYKLFIAYSMIHAVETGQVTWDSALNGMTLSSCMATMIIN SDNSCPEAWLARYGFSTVTQQAHDIGAANTNFVPYGMTTTANDLATVLKGFYSNSIASPD STDQLFSLMETQVYREGIPAGIGSDGVVQDKVGFMDGLLHDAAIVRSDKGDYAMVIMTDG SSWNKIAQASLLIYESL
Function	This enzyme hydrolyzes beta-lactam.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ceftiofur	DMR2SOZ	Bacterial infection	1A00-1C4Z	Approved	[1], [2]
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References

1	Bovine intestinal bacteria inactivate and degrade ceftiofur and ceftriaxone with multiple beta-lactamases. Antimicrob Agents Chemother. 2011 Nov;55(11):4990-8.
2	Characterization and induction of prophages in human gut-associated Bifidobacterium hosts. Sci Rep. 2018 Aug 24;8(1):12772.