| DME Name |
Fumarate reductase flavoprotein (frdA)
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| Synonyms |
Flavocytochrome c; Methylmenaquinol:fumarate reductase; Flavocytochrome c3; Fcc3; WS0831; Bacterial frdA |
| Gene Name |
frdA
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| UniProt ID |
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| INTEDE ID |
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| 3D Structure |
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| EC Number |
EC: 1.3.5.4
- Oxidoreductase
- CH-CH donor oxidoreductase
- Quinone acceptor oxidoreductase
- EC: 1.3.5.4
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| Lineage |
Species: Wolinella succinogenes
- Kingdom: Bacteria
- Phylum: Proteobacteria
- Class: Epsilonproteobacteria
- Order: Campylobacterales
- Family: Helicobacteraceae
- Genus: Wolinella
- Species: Wolinella succinogenes
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| Tissue Distribution |
Primarily distributed in human gut.
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| Sequence |
MKVQYCDSLVIGGGLAGLRAAVATQQKGLSTIVLSLIPVKRSHSAAAQGGMQASLGNSKM
SDGDNEDLHFMDTVKGSDWGCDQKVARMFVNTAPKAIRELAAWGVPWTRIHKGDRMAIIN
AQKTTITEEDFRHGLIHSRDFGGTKKWRTCYTADATGHTMLFAVANECLKLGVSIQDRKE
AIALIHQDGKCYGAVVRDLVTGDIIAYVAKGTLIATGGYGRIYKNTTNAVVCEGTGTAIA
LETGIAQLGNMEAVQFHPTPLFPSGILLTEGCRGDGGILRDVDGHRFMPDYEPEKKELAS
RDVVSRRMIEHIRKGKGVQSPYGQHLWLDISILGRKHIETNLRDVQEICEYFAGIDPAEK
WAPVLPMQHYSMGGIRTDYRGEAKLKGLFSAGEAACWDMHGFNRLGGNSVSEAVVAGMIV
GEYFAEHCANTQVDLETKTLEKFVKGQEAYMKSLVESKGTEDVFKIKNRMKDVMDDNVGI
FRDGPHLEKAVKELEELYKKSKNVGIKNKRLHANPELEEAYRVPMMLKVALCVAKGALDR
TESRGAHNREDYPKRDDINWLNRTLASWPNPEQTLPTLEYEALDVNEMEIAPGYRGYGAK
GNYIENPLSVKRQEEIDKIQSELEAAGKDRHAIQEALMPYELPAKYKARNERLGDK
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| Function |
This enzyme utilizes low potential quinols, such as menaquinol and rhodoquinol, to reduce fumarate as the final step of an anaerobic respiratory chain. The enzyme is known as complex II of the electron transfer chain, similarly to succinate dehydrogenase (quinone), to which it is closely related.
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| KEGG Pathway |
- Biosynthesis of secondary metabolites (wsu01110 )
- Butanoate metabolism (wsu00650 )
- Carbon metabolism (wsu01200 )
- Citrate cycle (TCA cycle) (wsu00020 )
- Metabolic pathways (wsu01100 )
- Microbial metabolism in diverse environments (wsu01120 )
- Oxidative phosphorylation (wsu00190 )
- Pyruvate metabolism (wsu00620 )
- Two-component system (wsu02020 )
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